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Partial thyrocyte-specific Gαs deficiency leads to rapid-onset hypothyroidism, hyperplasia, and papillary thyroid carcinoma-like lesions in mice.
Patyra K, Jaeschke H, Löf C, Jännäri M, Ruohonen ST, Undeutsch H, Khalil M, Kero A, Poutanen M, Toppari J, Chen M, Weinstein LS, Paschke R, Kero J. Patyra K, et al. Among authors: ruohonen st. FASEB J. 2018 May 25:fj201800211R. doi: 10.1096/fj.201800211R. Online ahead of print. FASEB J. 2018. PMID: 29799790
Gonadal hormone-dependent vs. -independent effects of kisspeptin signaling in the control of body weight and metabolic homeostasis.
Velasco I, León S, Barroso A, Ruiz-Pino F, Heras V, Torres E, León M, Ruohonen ST, García-Galiano D, Romero-Ruiz A, Sánchez-Garrido MA, Ohlsson C, Castellano JM, Roa J, Poutanen M, Pinilla L, Vázquez MJ, Tena-Sempere M. Velasco I, et al. Among authors: ruohonen st. Metabolism. 2019 Sep;98:84-94. doi: 10.1016/j.metabol.2019.06.007. Epub 2019 Jun 19. Metabolism. 2019. PMID: 31226351
Hydroxysteroid (17β) dehydrogenase 12 is essential for metabolic homeostasis in adult mice.
Heikelä H, Ruohonen ST, Adam M, Viitanen R, Liljenbäck H, Eskola O, Gabriel M, Mairinoja L, Pessia A, Velagapudi V, Roivainen A, Zhang FP, Strauss L, Poutanen M. Heikelä H, et al. Among authors: ruohonen st. Am J Physiol Endocrinol Metab. 2020 Sep 1;319(3):E494-E508. doi: 10.1152/ajpendo.00042.2020. Epub 2020 Jul 21. Am J Physiol Endocrinol Metab. 2020. PMID: 32691632 Free article.
Dissecting the KNDy hypothesis: KNDy neuron-derived kisspeptins are dispensable for puberty but essential for preserved female fertility and gonadotropin pulsatility.
Velasco I, Franssen D, Daza-Dueñas S, Skrapits K, Takács S, Torres E, Rodríguez-Vazquez E, Ruiz-Cruz M, León S, Kukoricza K, Zhang FP, Ruohonen S, Luque-Cordoba D, Priego-Capote F, Gaytan F, Ruiz-Pino F, Hrabovszky E, Poutanen M, Vázquez MJ, Tena-Sempere M. Velasco I, et al. Metabolism. 2023 Jul;144:155556. doi: 10.1016/j.metabol.2023.155556. Epub 2023 Apr 29. Metabolism. 2023. PMID: 37121307 Free article.
40 results