Kimura H - Search Results

1

Combined treatment with a selective PDE10A inhibitor TAK-063 and either haloperidol or olanzapine at subeffective doses produces potent antipsychotic-like effects without affecting plasma prolactin levels and cataleptic responses in rodents.

Suzuki K, Harada A, Suzuki H, Capuani C, Ugolini A, Corsi M, Kimura H. Suzuki K, et al. Among authors: kimura h. Pharmacol Res Perspect. 2018 Feb;6(1):e00372. doi: 10.1002/prp2.372. Pharmacol Res Perspect. 2018. PMID: 29417763 Free PMC article.

2

The chondroprotective agent ITZ-1 inhibits interleukin-1beta-induced matrix metalloproteinase-13 production and suppresses nitric oxide-induced chondrocyte death.

Kimura H, Yukitake H, Suzuki H, Tajima Y, Gomaibashi K, Morimoto S, Funabashi Y, Yamada K, Takizawa M. Kimura H, et al. J Pharmacol Sci. 2009 Jun;110(2):201-11. doi: 10.1254/jphs.09076fp. J Pharmacol Sci. 2009. PMID: 19542681 Free article.

3

ITZ-1, a client-selective Hsp90 inhibitor, efficiently induces heat shock factor 1 activation.

Kimura H, Yukitake H, Tajima Y, Suzuki H, Chikatsu T, Morimoto S, Funabashi Y, Omae H, Ito T, Yoneda Y, Takizawa M. Kimura H, et al. Chem Biol. 2010 Jan 29;17(1):18-27. doi: 10.1016/j.chembiol.2009.12.012. Chem Biol. 2010. PMID: 20142037

4

BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression.

Kimura H, Sato Y, Tajima Y, Suzuki H, Yukitake H, Imaeda T, Kajino M, Oki H, Takizawa M, Tanida S. Kimura H, et al. Chem Biol. 2010 Dec 22;17(12):1282-94. doi: 10.1016/j.chembiol.2010.10.011. Chem Biol. 2010. PMID: 21168764

5

BTZO-15, an ARE-activator, ameliorates DSS- and TNBS-induced colitis in rats.

Yukitake H, Kimura H, Suzuki H, Tajima Y, Sato Y, Imaeda T, Kajino M, Takizawa M. Yukitake H, et al. Among authors: kimura h. PLoS One. 2011;6(8):e23256. doi: 10.1371/journal.pone.0023256. Epub 2011 Aug 10. PLoS One. 2011. PMID: 21853095 Free PMC article.

6

BTZO-2, an antioxidant response element-activator, provides protection against lethal endotoxic shock in mice.

Yukitake H, Kimura H, Tajima Y, Sato Y, Suzuki H, Kajino M, Tanida S, Takizawa M. Yukitake H, et al. Among authors: kimura h. Eur J Pharmacol. 2013 Jan 30;700(1-3):80-5. doi: 10.1016/j.ejphar.2012.12.014. Epub 2012 Dec 28. Eur J Pharmacol. 2013. PMID: 23276667

7

Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor.

Kunitomo J, Yoshikawa M, Fushimi M, Kawada A, Quinn JF, Oki H, Kokubo H, Kondo M, Nakashima K, Kamiguchi N, Suzuki K, Kimura H, Taniguchi T. Kunitomo J, et al. Among authors: kimura h. J Med Chem. 2014 Nov 26;57(22):9627-43. doi: 10.1021/jm5013648. Epub 2014 Nov 10. J Med Chem. 2014. PMID: 25384088

8

Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A.

Harada A, Suzuki K, Miura S, Hasui T, Kamiguchi N, Ishii T, Taniguchi T, Kuroita T, Takano A, Stepanov V, Halldin C, Kimura H. Harada A, et al. Among authors: kimura h. Nucl Med Biol. 2015 Feb;42(2):146-54. doi: 10.1016/j.nucmedbio.2014.09.005. Epub 2014 Sep 28. Nucl Med Biol. 2015. PMID: 25451212

9

In vivo pharmacological characterization of TAK-063, a potent and selective phosphodiesterase 10A inhibitor with antipsychotic-like activity in rodents.

Suzuki K, Harada A, Shiraishi E, Kimura H. Suzuki K, et al. Among authors: kimura h. J Pharmacol Exp Ther. 2015 Mar;352(3):471-9. doi: 10.1124/jpet.114.218552. Epub 2014 Dec 18. J Pharmacol Exp Ther. 2015. PMID: 25525190

10

Characterization of binding and inhibitory properties of TAK-063, a novel phosphodiesterase 10A inhibitor.

Harada A, Suzuki K, Kamiguchi N, Miyamoto M, Tohyama K, Nakashima K, Taniguchi T, Kimura H. Harada A, et al. Among authors: kimura h. PLoS One. 2015 Mar 27;10(3):e0122197. doi: 10.1371/journal.pone.0122197. eCollection 2015. PLoS One. 2015. PMID: 25815469 Free PMC article.

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