Yang Z - Search Results

1

Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1.

Yang Z, Hildebrandt E, Jiang F, Aleksandrov AA, Khazanov N, Zhou Q, An J, Mezzell AT, Xavier BM, Ding H, Riordan JR, Senderowitz H, Kappes JC, Brouillette CG, Urbatsch IL. Yang Z, et al. Biochim Biophys Acta Biomembr. 2018 May;1860(5):1193-1204. doi: 10.1016/j.bbamem.2018.02.006. Epub 2018 Feb 7. Biochim Biophys Acta Biomembr. 2018. PMID: 29425673 Free PMC article.

2

Dimethyl sulfoxide at 2.5% (v/v) alters the structural cooperativity and unfolding mechanism of dimeric bacterial NAD+ synthetase.

Yang ZW, Tendian SW, Carson WM, Brouillette WJ, Delucas LJ, Brouillette CG. Yang ZW, et al. Protein Sci. 2004 Mar;13(3):830-41. doi: 10.1110/ps.03330104. Protein Sci. 2004. PMID: 14978314 Free PMC article.

3

Engineering mouse apolipoprotein A-I into a monomeric, active protein useful for structural determination.

Ren X, Zhao L, Sivashanmugam A, Miao Y, Korando L, Yang Z, Reardon CA, Getz GS, Brouillette CG, Jerome WG, Wang J. Ren X, et al. Among authors: yang z. Biochemistry. 2005 Nov 15;44(45):14907-19. doi: 10.1021/bi0508385. Biochemistry. 2005. PMID: 16274238

4

Förster resonance energy transfer measurements are consistent with a helical bundle model for lipid-free apolipoprotein A-I.

Brouillette CG, Dong WJ, Yang ZW, Ray MJ, Protasevich II, Cheung HC, Engler JA. Brouillette CG, et al. Biochemistry. 2005 Dec 20;44(50):16413-25. doi: 10.1021/bi051018v. Biochemistry. 2005. PMID: 16342934

5

Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups.

Velu SE, Mou L, Luan CH, Yang ZW, DeLucas LJ, Brouillette CG, Brouillette WJ. Velu SE, et al. J Med Chem. 2007 May 31;50(11):2612-21. doi: 10.1021/jm061349l. Epub 2007 May 10. J Med Chem. 2007. PMID: 17489580

6

Structure of nicotinic acid mononucleotide adenylyltransferase from Bacillus anthracis.

Lu S, Smith CD, Yang Z, Pruett PS, Nagy L, McCombs D, Delucas LJ, Brouillette WJ, Brouillette CG. Lu S, et al. Among authors: yang z. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Oct 1;64(Pt 10):893-8. doi: 10.1107/S1744309108029102. Epub 2008 Sep 30. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008. PMID: 18931430 Free PMC article.

7

Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs).

Moro WB, Yang Z, Kane TA, Brouillette CG, Brouillette WJ. Moro WB, et al. Among authors: yang z. Bioorg Med Chem Lett. 2009 Apr 1;19(7):2001-5. doi: 10.1016/j.bmcl.2009.02.034. Epub 2009 Feb 12. Bioorg Med Chem Lett. 2009. PMID: 19249205 Free PMC article.

8

SAR studies for a new class of antibacterial NAD biosynthesis inhibitors.

Moro WB, Yang Z, Kane TA, Zhou Q, Harville S, Brouillette CG, Brouillette WJ. Moro WB, et al. Among authors: yang z. J Comb Chem. 2009 Jul-Aug;11(4):617-25. doi: 10.1021/cc9000357. J Comb Chem. 2009. PMID: 19408950 Free PMC article.

9

Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide-binding domain 1.

Protasevich I, Yang Z, Wang C, Atwell S, Zhao X, Emtage S, Wetmore D, Hunt JF, Brouillette CG. Protasevich I, et al. Among authors: yang z. Protein Sci. 2010 Oct;19(10):1917-31. doi: 10.1002/pro.479. Protein Sci. 2010. PMID: 20687133 Free PMC article.

10

Integrated biophysical studies implicate partial unfolding of NBD1 of CFTR in the molecular pathogenesis of F508del cystic fibrosis.

Wang C, Protasevich I, Yang Z, Seehausen D, Skalak T, Zhao X, Atwell S, Spencer Emtage J, Wetmore DR, Brouillette CG, Hunt JF. Wang C, et al. Among authors: yang z. Protein Sci. 2010 Oct;19(10):1932-47. doi: 10.1002/pro.480. Protein Sci. 2010. PMID: 20687163 Free PMC article.

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