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Page 1
Discovery of an L-alanine ester prodrug of the Hsp90 inhibitor, MPC-3100.
Kim SH, Tangallapally R, Kim IC, Trovato R, Parker D, Patton JS, Reeves L, Bradford C, Wettstein D, Baichwal V, Papac D, Bajji A, Carlson R, Yager KM. Kim SH, et al. Among authors: papac d. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5254-7. doi: 10.1016/j.bmcl.2015.09.053. Epub 2015 Sep 28. Bioorg Med Chem Lett. 2015. PMID: 26483201
Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1.
Tardif KD, Rogers A, Cassiano J, Roth BL, Cimbora DM, McKinnon R, Peterson A, Douce TB, Robinson R, Dorweiler I, Davis T, Hess MA, Ostanin K, Papac DI, Baichwal V, McAlexander I, Willardsen JA, Saunders M, Christophe H, Kumar DV, Wettstein DA, Carlson RO, Williams BL. Tardif KD, et al. Among authors: papac di. Mol Cancer Ther. 2011 Dec;10(12):2267-75. doi: 10.1158/1535-7163.MCT-11-0453. Epub 2011 Oct 6. Mol Cancer Ther. 2011. PMID: 21980130
Discovery of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a purine-based Hsp90 inhibitor.
Kim SH, Bajji A, Tangallapally R, Markovitz B, Trovato R, Shenderovich M, Baichwal V, Bartel P, Cimbora D, McKinnon R, Robinson R, Papac D, Wettstein D, Carlson R, Yager KM. Kim SH, et al. Among authors: papac d. J Med Chem. 2012 Sep 13;55(17):7480-501. doi: 10.1021/jm3004619. Epub 2012 Aug 31. J Med Chem. 2012. PMID: 22913511
Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors.
Vijay Kumar D, Hoarau C, Bursavich M, Slattum P, Gerrish D, Yager K, Saunders M, Shenderovich M, Roth BL, McKinnon R, Chan A, Cimbora DM, Bradford C, Reeves L, Patton S, Papac DI, Williams BL, Carlson RO. Vijay Kumar D, et al. Among authors: papac di. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4377-85. doi: 10.1016/j.bmcl.2012.04.131. Epub 2012 May 5. Bioorg Med Chem Lett. 2012. PMID: 22632936
Design, synthesis and biological activity of novel dimethyl-[2-[6-substituted-indol-1-yl]-ethyl]-amine as potent, selective, and orally-bioavailable 5-HT(1D) agonists.
Isaac M, Slassi M, Xin T, Arora J, O'Brien A, Edwards L, MacLean N, Wilson J, Demschyshyn L, Labrie P, Naismith A, Maddaford S, Papac D, Harrison S, Wang H, Draper S, Tehim A. Isaac M, et al. Among authors: papac d. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4409-13. doi: 10.1016/j.bmcl.2003.09.025. Bioorg Med Chem Lett. 2003. PMID: 14643336
27 results