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Page 1
Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.
Gaul DS, Weber J, van Tits LJ, Sluka S, Pasterk L, Reiner MF, Calatayud N, Lohmann C, Klingenberg R, Pahla J, Vdovenko D, Tanner FC, Camici GG, Eriksson U, Auwerx J, Mach F, Windecker S, Rodondi N, Lüscher TF, Winnik S, Matter CM. Gaul DS, et al. Among authors: auwerx j. Cardiovasc Res. 2018 Jul 1;114(8):1178-1188. doi: 10.1093/cvr/cvy036. Cardiovasc Res. 2018. PMID: 29444200 Free PMC article.
Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development.
Winnik S, Gaul DS, Preitner F, Lohmann C, Weber J, Miranda MX, Liu Y, van Tits LJ, Mateos JM, Brokopp CE, Auwerx J, Thorens B, Lüscher TF, Matter CM. Winnik S, et al. Among authors: auwerx j. Basic Res Cardiol. 2014 Jan;109(1):399. doi: 10.1007/s00395-013-0399-0. Epub 2013 Dec 27. Basic Res Cardiol. 2014. PMID: 24370889 Free PMC article.
The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.
Miranda MX, van Tits LJ, Lohmann C, Arsiwala T, Winnik S, Tailleux A, Stein S, Gomes AP, Suri V, Ellis JL, Lutz TA, Hottiger MO, Sinclair DA, Auwerx J, Schoonjans K, Staels B, Lüscher TF, Matter CM. Miranda MX, et al. Among authors: auwerx j. Eur Heart J. 2015 Jan 1;36(1):51-9. doi: 10.1093/eurheartj/ehu095. Epub 2014 Mar 6. Eur Heart J. 2015. PMID: 24603306 Free PMC article.
Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-β-dependent feedback regulation of SOD2.
Winnik S, Gaul DS, Siciliani G, Lohmann C, Pasterk L, Calatayud N, Weber J, Eriksson U, Auwerx J, van Tits LJ, Lüscher TF, Matter CM. Winnik S, et al. Among authors: auwerx j. Basic Res Cardiol. 2016 May;111(3):33. doi: 10.1007/s00395-016-0552-7. Epub 2016 Apr 12. Basic Res Cardiol. 2016. PMID: 27071400 Free PMC article.
Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B.
van Weeghel M, Abdurrachim D, Nederlof R, Argmann CA, Houtkooper RH, Hagen J, Nabben M, Denis S, Ciapaite J, Kolwicz SC Jr, Lopaschuk GD, Auwerx J, Nicolay K, Des Rosiers C, Wanders RJ, Zuurbier CJ, Prompers JJ, Houten SM. van Weeghel M, et al. Among authors: auwerx j. Cardiovasc Res. 2018 Aug 1;114(10):1324-1334. doi: 10.1093/cvr/cvy089. Cardiovasc Res. 2018. PMID: 29635338
Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress.
Dikalova AE, Pandey A, Xiao L, Arslanbaeva L, Sidorova T, Lopez MG, Billings FT 4th, Verdin E, Auwerx J, Harrison DG, Dikalov SI. Dikalova AE, et al. Among authors: auwerx j. Circ Res. 2020 Feb 14;126(4):439-452. doi: 10.1161/CIRCRESAHA.119.315767. Epub 2019 Dec 19. Circ Res. 2020. PMID: 31852393 Free PMC article.
Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1.
Arsiwala T, Pahla J, van Tits LJ, Bisceglie L, Gaul DS, Costantino S, Miranda MX, Nussbaum K, Stivala S, Blyszczuk P, Weber J, Tailleux A, Stein S, Paneni F, Beer JH, Greter M, Becher B, Mostoslavsky R, Eriksson U, Staels B, Auwerx J, Hottiger MO, Lüscher TF, Matter CM. Arsiwala T, et al. Among authors: auwerx j. J Mol Cell Cardiol. 2020 Feb;139:24-32. doi: 10.1016/j.yjmcc.2020.01.002. Epub 2020 Jan 21. J Mol Cell Cardiol. 2020. PMID: 31972266
636 results