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Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.
Hollinshead KER, Munford H, Eales KL, Bardella C, Li C, Escribano-Gonzalez C, Thakker A, Nonnenmacher Y, Kluckova K, Jeeves M, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson DJ, Hua W, Tomlinson IP, Ludwig C, Mao Y, Tennant DA. Hollinshead KER, et al. Among authors: tennant da. Cell Rep. 2018 Mar 20;22(12):3107-3114. doi: 10.1016/j.celrep.2018.02.084. Cell Rep. 2018. PMID: 29562167 Free PMC article.
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.
Elhassan YS, Kluckova K, Fletcher RS, Schmidt MS, Garten A, Doig CL, Cartwright DM, Oakey L, Burley CV, Jenkinson N, Wilson M, Lucas SJE, Akerman I, Seabright A, Lai YC, Tennant DA, Nightingale P, Wallis GA, Manolopoulos KN, Brenner C, Philp A, Lavery GG. Elhassan YS, et al. Among authors: tennant da. Cell Rep. 2019 Aug 13;28(7):1717-1728.e6. doi: 10.1016/j.celrep.2019.07.043. Cell Rep. 2019. PMID: 31412242 Free PMC article. Clinical Trial.
Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.
Goncalves J, Moog S, Morin A, Gentric G, Müller S, Morrell AP, Kluckova K, Stewart TJ, Andoniadou CL, Lussey-Lepoutre C, Bénit P, Thakker A, Vettore L, Roberts J, Rodriguez R, Mechta-Grigoriou F, Gimenez-Roqueplo AP, Letouzé E, Tennant DA, Favier J. Goncalves J, et al. Among authors: tennant da. Cancer Res. 2021 Jul 1;81(13):3480-3494. doi: 10.1158/0008-5472.CAN-20-2936. Epub 2021 Jun 14. Cancer Res. 2021. PMID: 34127497 Free PMC article.
PK-M2 Makes Cells Sweeter on HIF1.
Tennant DA. Tennant DA. Cell. 2011 May 27;145(5):647-9. doi: 10.1016/j.cell.2011.05.009. Cell. 2011. PMID: 21620132 Free article.
Hypoxia and metabolic adaptation of cancer cells.
Eales KL, Hollinshead KE, Tennant DA. Eales KL, et al. Among authors: tennant da. Oncogenesis. 2016 Jan 25;5(1):e190. doi: 10.1038/oncsis.2015.50. Oncogenesis. 2016. PMID: 26807645 Free PMC article. Review.
113 results