Shroff R - Search Results

1

Evolving Bacterial Fitness with an Expanded Genetic Code.

Tack DS, Cole AC, Shroff R, Morrow BR, Ellington AD. Tack DS, et al. Among authors: shroff r. Sci Rep. 2018 Feb 19;8(1):3288. doi: 10.1038/s41598-018-21549-w. Sci Rep. 2018. PMID: 29459649 Free PMC article.

2

Synthetic evolutionary origin of a proofreading reverse transcriptase.

Ellefson JW, Gollihar J, Shroff R, Shivram H, Iyer VR, Ellington AD. Ellefson JW, et al. Among authors: shroff r. Science. 2016 Jun 24;352(6293):1590-3. doi: 10.1126/science.aaf5409. Science. 2016. PMID: 27339990

3

Evolution of a Thermophilic Strand-Displacing Polymerase Using High-Temperature Isothermal Compartmentalized Self-Replication.

Milligan JN, Shroff R, Garry DJ, Ellington AD. Milligan JN, et al. Among authors: shroff r. Biochemistry. 2018 Aug 7;57(31):4607-4619. doi: 10.1021/acs.biochem.8b00200. Epub 2018 Apr 18. Biochemistry. 2018. PMID: 29629759

4

Microbiota and Metatranscriptome Changes Accompanying the Onset of Gingivitis.

Nowicki EM, Shroff R, Singleton JA, Renaud DE, Wallace D, Drury J, Zirnheld J, Colleti B, Ellington AD, Lamont RJ, Scott DA, Whiteley M. Nowicki EM, et al. Among authors: shroff r. mBio. 2018 Apr 17;9(2):e00575-18. doi: 10.1128/mBio.00575-18. mBio. 2018. PMID: 29666288 Free PMC article.

5

Custom selenoprotein production enabled by laboratory evolution of recoded bacterial strains.

Thyer R, Shroff R, Klein DR, d'Oelsnitz S, Cotham VC, Byrom M, Brodbelt JS, Ellington AD. Thyer R, et al. Among authors: shroff r. Nat Biotechnol. 2018 Aug;36(7):624-631. doi: 10.1038/nbt.4154. Epub 2018 Jun 4. Nat Biotechnol. 2018. PMID: 29863724 Free PMC article.

6

Cellular reagents for diagnostics and synthetic biology.

Bhadra S, Pothukuchy A, Shroff R, Cole AW, Byrom M, Ellefson JW, Gollihar JD, Ellington AD. Bhadra S, et al. Among authors: shroff r. PLoS One. 2018 Aug 15;13(8):e0201681. doi: 10.1371/journal.pone.0201681. eCollection 2018. PLoS One. 2018. PMID: 30110361 Free PMC article.

7

Discovery of Novel Gain-of-Function Mutations Guided by Structure-Based Deep Learning.

Shroff R, Cole AW, Diaz DJ, Morrow BR, Donnell I, Annapareddy A, Gollihar J, Ellington AD, Thyer R. Shroff R, et al. ACS Synth Biol. 2020 Nov 20;9(11):2927-2935. doi: 10.1021/acssynbio.0c00345. Epub 2020 Oct 16. ACS Synth Biol. 2020. PMID: 33064458

8

Improved Bst DNA Polymerase Variants Derived via a Machine Learning Approach.

Paik I, Ngo PHT, Shroff R, Diaz DJ, Maranhao AC, Walker DJF, Bhadra S, Ellington AD. Paik I, et al. Among authors: shroff r. Biochemistry. 2023 Jan 17;62(2):410-418. doi: 10.1021/acs.biochem.1c00451. Epub 2021 Nov 11. Biochemistry. 2023. PMID: 34762799 Free PMC article.

9

Recovery of Information Stored in Modified DNA with an Evolved Polymerase.

Shroff R, Ellefson JW, Wang SS, Boulgakov AA, Hughes RA, Ellington AD. Shroff R, et al. ACS Synth Biol. 2022 Feb 18;11(2):554-561. doi: 10.1021/acssynbio.1c00575. Epub 2022 Feb 3. ACS Synth Biol. 2022. PMID: 35113518

10

Machine learning-aided engineering of hydrolases for PET depolymerization.

Lu H, Diaz DJ, Czarnecki NJ, Zhu C, Kim W, Shroff R, Acosta DJ, Alexander BR, Cole HO, Zhang Y, Lynd NA, Ellington AD, Alper HS. Lu H, et al. Among authors: shroff r. Nature. 2022 Apr;604(7907):662-667. doi: 10.1038/s41586-022-04599-z. Epub 2022 Apr 27. Nature. 2022. PMID: 35478237

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