Acetaminophen-induced liver injury is mediated by the ion channel TRPV4.
Echtermeyer F, Eberhardt M, Risser L, Herzog C, Gueler F, Khalil M, Engel M, Vondran F, Leffler A.
Echtermeyer F, et al. Among authors: khalil m.
FASEB J. 2019 Sep;33(9):10257-10268. doi: 10.1096/fj.201802233R. Epub 2019 Jun 17.
FASEB J. 2019.
PMID: 31207191
Taken together, our data suggest that TRPV4 mediates APAP-induced hepatotoxicity and thus may be a suitable target for treatment of this critical side effect.-Echtermeyer, F., Eberhardt, M., Risser, L., Herzog, C., Gueler, F., Khalil, M., Engel, M., Vo …
Taken together, our data suggest that TRPV4 mediates APAP-induced hepatotoxicity and thus may be a suitable target for treatment of this cri …