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In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells.
Feldmann DP, Cheng Y, Kandil R, Xie Y, Mohammadi M, Harz H, Sharma A, Peeler DJ, Moszczynska A, Leonhardt H, Pun SH, Merkel OM. Feldmann DP, et al. Among authors: merkel om. J Control Release. 2018 Apr 28;276:50-58. doi: 10.1016/j.jconrel.2018.02.017. Epub 2018 Feb 20. J Control Release. 2018. PMID: 29474962 Free PMC article.
Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging.
Merkel OM, Librizzi D, Pfestroff A, Schurrat T, Buyens K, Sanders NN, De Smedt SC, Béhé M, Kissel T. Merkel OM, et al. J Control Release. 2009 Sep 1;138(2):148-59. doi: 10.1016/j.jconrel.2009.05.016. Epub 2009 May 19. J Control Release. 2009. PMID: 19463870
Polymer-related off-target effects in non-viral siRNA delivery.
Merkel OM, Beyerle A, Beckmann BM, Zheng M, Hartmann RK, Stöger T, Kissel TH. Merkel OM, et al. Biomaterials. 2011 Mar;32(9):2388-98. doi: 10.1016/j.biomaterials.2010.11.081. Epub 2010 Dec 22. Biomaterials. 2011. PMID: 21183213
Nonviral pulmonary delivery of siRNA.
Merkel OM, Kissel T. Merkel OM, et al. Acc Chem Res. 2012 Jul 17;45(7):961-70. doi: 10.1021/ar200110p. Epub 2011 Sep 9. Acc Chem Res. 2012. PMID: 21905687
126 results