Tsantrizos YS - Search Results

1

Isoprenoids and tau pathology in sporadic Alzheimer's disease.

Pelleieux S, Picard C, Lamarre-Théroux L, Dea D, Leduc V, Tsantrizos YS, Poirier J. Pelleieux S, et al. Among authors: tsantrizos ys. Neurobiol Aging. 2018 May;65:132-139. doi: 10.1016/j.neurobiolaging.2018.01.012. Epub 2018 Feb 2. Neurobiol Aging. 2018. PMID: 29476987

2

Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases.

De Schutter JW, Park J, Leung CY, Gormley P, Lin YS, Hu Z, Berghuis AM, Poirier J, Tsantrizos YS. De Schutter JW, et al. Among authors: tsantrizos ys. J Med Chem. 2014 Jul 10;57(13):5764-76. doi: 10.1021/jm500629e. Epub 2014 Jun 23. J Med Chem. 2014. PMID: 24911527

3

Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product.

Park J, Zielinski M, Magder A, Tsantrizos YS, Berghuis AM. Park J, et al. Among authors: tsantrizos ys. Nat Commun. 2017 Jan 18;8:14132. doi: 10.1038/ncomms14132. Nat Commun. 2017. PMID: 28098152 Free PMC article.

4

Inhibition of farnesyl pyrophosphate (FPP) and/or geranylgeranyl pyrophosphate (GGPP) biosynthesis and its implication in the treatment of cancers.

Waller DD, Park J, Tsantrizos YS. Waller DD, et al. Among authors: tsantrizos ys. Crit Rev Biochem Mol Biol. 2019 Feb;54(1):41-60. doi: 10.1080/10409238.2019.1568964. Epub 2019 Feb 18. Crit Rev Biochem Mol Biol. 2019. PMID: 30773935 Review.

5

Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase.

De Schutter JW, Zaretsky S, Welbourn S, Pause A, Tsantrizos YS. De Schutter JW, et al. Among authors: tsantrizos ys. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5781-6. doi: 10.1016/j.bmcl.2010.07.133. Epub 2010 Aug 11. Bioorg Med Chem Lett. 2010. PMID: 20801032

6

Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.

Park J, Rodionov D, De Schutter JW, Lin YS, Tsantrizos YS, Berghuis AM. Park J, et al. Among authors: tsantrizos ys. PLoS One. 2017 Oct 16;12(10):e0186447. doi: 10.1371/journal.pone.0186447. eCollection 2017. PLoS One. 2017. PMID: 29036218 Free PMC article.

7

Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.

Lacbay CM, Waller DD, Park J, Gómez Palou M, Vincent F, Huang XF, Ta V, Berghuis AM, Sebag M, Tsantrizos YS. Lacbay CM, et al. Among authors: tsantrizos ys. J Med Chem. 2018 Aug 9;61(15):6904-6917. doi: 10.1021/acs.jmedchem.8b00886. Epub 2018 Jul 25. J Med Chem. 2018. PMID: 30016091

8

Chirality-Driven Mode of Binding of α-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).

Feng Y, Park J, Li SG, Boutin R, Viereck P, Schilling MA, Berghuis AM, Tsantrizos YS. Feng Y, et al. Among authors: tsantrizos ys. J Med Chem. 2019 Nov 14;62(21):9691-9702. doi: 10.1021/acs.jmedchem.9b01104. Epub 2019 Oct 16. J Med Chem. 2019. PMID: 31577901

9

Thienopyrimidine bisphosphonate (ThPBP) inhibitors of the human farnesyl pyrophosphate synthase: optimization and characterization of the mode of inhibition.

Leung CY, Park J, De Schutter JW, Sebag M, Berghuis AM, Tsantrizos YS. Leung CY, et al. Among authors: tsantrizos ys. J Med Chem. 2013 Oct 24;56(20):7939-50. doi: 10.1021/jm400946f. Epub 2013 Oct 3. J Med Chem. 2013. PMID: 23998921

10

Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate.

Park J, Lin YS, Tsantrizos YS, Berghuis AM. Park J, et al. Among authors: tsantrizos ys. Acta Crystallogr F Struct Biol Commun. 2014 Mar;70(Pt 3):299-304. doi: 10.1107/S2053230X14002106. Epub 2014 Feb 19. Acta Crystallogr F Struct Biol Commun. 2014. PMID: 24598914 Free PMC article.

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