Lopez-Sanchez I - Search Results

1

Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple.

Aznar N, Ear J, Dunkel Y, Sun N, Satterfield K, He F, Kalogriopoulos NA, Lopez-Sanchez I, Ghassemian M, Sahoo D, Kufareva I, Ghosh P. Aznar N, et al. Sci Signal. 2018 Feb 27;11(519):eaao4220. doi: 10.1126/scisignal.aao4220. Sci Signal. 2018. PMID: 29487190 Free PMC article.

2

Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin.

López-Sánchez I, Garcia-Marcos M, Mittal Y, Aznar N, Farquhar MG, Ghosh P. López-Sánchez I, et al. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5510-5. doi: 10.1073/pnas.1303392110. Epub 2013 Mar 18. Proc Natl Acad Sci U S A. 2013. PMID: 23509302 Free PMC article.

3

GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis.

Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F, Ho SB, Seki E, Brenner DA, Ghosh P. Lopez-Sanchez I, et al. Nat Commun. 2014 Jul 21;5:4451. doi: 10.1038/ncomms5451. Nat Commun. 2014. PMID: 25043713 Free PMC article.

4

Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.

Lin C, Ear J, Midde K, Lopez-Sanchez I, Aznar N, Garcia-Marcos M, Kufareva I, Abagyan R, Ghosh P. Lin C, et al. Mol Biol Cell. 2014 Nov 5;25(22):3654-71. doi: 10.1091/mbc.E14-05-0978. Epub 2014 Sep 3. Mol Biol Cell. 2014. PMID: 25187647 Free PMC article.

5

Activation of Gαi at the Golgi by GIV/Girdin imposes finiteness in Arf1 signaling.

Lo IC, Gupta V, Midde KK, Taupin V, Lopez-Sanchez I, Kufareva I, Abagyan R, Randazzo PA, Farquhar MG, Ghosh P. Lo IC, et al. Dev Cell. 2015 Apr 20;33(2):189-203. doi: 10.1016/j.devcel.2015.02.009. Epub 2015 Apr 9. Dev Cell. 2015. PMID: 25865347 Free PMC article.

6

Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors.

Ma GS, Aznar N, Kalogriopoulos N, Midde KK, Lopez-Sanchez I, Sato E, Dunkel Y, Gallo RL, Ghosh P. Ma GS, et al. Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2602-10. doi: 10.1073/pnas.1505543112. Epub 2015 Apr 29. Proc Natl Acad Sci U S A. 2015. PMID: 25926659 Free PMC article.

7

Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.

Aznar N, Midde KK, Dunkel Y, Lopez-Sanchez I, Pavlova Y, Marivin A, Barbazán J, Murray F, Nitsche U, Janssen KP, Willert K, Goel A, Abal M, Garcia-Marcos M, Ghosh P. Aznar N, et al. Elife. 2015 Jun 30;4:e07091. doi: 10.7554/eLife.07091. Elife. 2015. PMID: 26126266 Free PMC article.

8

Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy.

Bhandari D, Lopez-Sanchez I, To A, Lo IC, Aznar N, Leyme A, Gupta V, Niesman I, Maddox AL, Garcia-Marcos M, Farquhar MG, Ghosh P. Bhandari D, et al. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4874-83. doi: 10.1073/pnas.1514157112. Epub 2015 Aug 18. Proc Natl Acad Sci U S A. 2015. PMID: 26286990 Free PMC article.

9

Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity.

Ma GS, Lopez-Sanchez I, Aznar N, Kalogriopoulos N, Pedram S, Midde K, Ciaraldi TP, Henry RR, Ghosh P. Ma GS, et al. Mol Biol Cell. 2015 Nov 15;26(23):4209-23. doi: 10.1091/mbc.E15-08-0553. Epub 2015 Sep 16. Mol Biol Cell. 2015. PMID: 26378251 Free PMC article.

10

Focal adhesions are foci for tyrosine-based signal transduction via GIV/Girdin and G proteins.

Lopez-Sanchez I, Kalogriopoulos N, Lo IC, Kabir F, Midde KK, Wang H, Ghosh P. Lopez-Sanchez I, et al. Mol Biol Cell. 2015 Dec 1;26(24):4313-24. doi: 10.1091/mbc.E15-07-0496. Epub 2015 Oct 7. Mol Biol Cell. 2015. PMID: 26446841 Free PMC article.

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