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Sodium valproate, a histone deacetylase inhibitor, decreases the secretion of soluble Fas by human osteosarcoma cells and increases their sensitivity to Fas-mediated cell death.
Yamanegi K, Yamane J, Hata M, Ohyama H, Yamada N, Kato-Kogoe N, Futani H, Nakasho K, Okamura H, Terada N. Yamanegi K, et al. Among authors: nakasho k. J Cancer Res Clin Oncol. 2009 Jul;135(7):879-89. doi: 10.1007/s00432-008-0522-z. Epub 2008 Dec 9. J Cancer Res Clin Oncol. 2009. PMID: 19066961
Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA/B, without increasing their soluble forms to enhance susceptibility of human osteosarcoma cells to NK cell-mediated cytotoxicity.
Yamanegi K, Yamane J, Kobayashi K, Kato-Kogoe N, Ohyama H, Nakasho K, Yamada N, Hata M, Nishioka T, Fukunaga S, Futani H, Okamura H, Terada N. Yamanegi K, et al. Among authors: nakasho k. Oncol Rep. 2010 Dec;24(6):1621-7. doi: 10.3892/or_00001026. Oncol Rep. 2010. PMID: 21042760
Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells.
Yamanegi K, Yamane J, Kobayashi K, Ohyama H, Nakasho K, Yamada N, Hata M, Fukunaga S, Futani H, Okamura H, Terada N. Yamanegi K, et al. Among authors: nakasho k. Oncol Rep. 2012 Nov;28(5):1585-90. doi: 10.3892/or.2012.1981. Epub 2012 Aug 22. Oncol Rep. 2012. PMID: 22923031
83 results