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Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy.
Zhou J, Liu M, Sun H, Feng Y, Xu L, Chan AWH, Tong JH, Wong J, Chong CCN, Lai PBS, Wang HK, Tsang SW, Goodwin T, Liu R, Huang L, Chen Z, Sung JJ, Chow KL, To KF, Cheng AS. Zhou J, et al. Among authors: cheng as. Gut. 2018 May;67(5):931-944. doi: 10.1136/gutjnl-2017-314032. Epub 2017 Sep 22. Gut. 2018. PMID: 28939663 Free PMC article.
Bufalin inhibits hepatitis B virus-associated hepatocellular carcinoma development through androgen receptor dephosphorylation and cell cycle-related kinase degradation.
Yu Z, Feng H, Zhuo Y, Li M, Zhu X, Huang L, Zhang X, Zhou Z, Zheng C, Jiang Y, Le F, Yu DY, Cheng AS, Sun X, Gao Y. Yu Z, et al. Among authors: cheng as. Cell Oncol (Dordr). 2020 Dec;43(6):1129-1145. doi: 10.1007/s13402-020-00546-0. Epub 2020 Jul 4. Cell Oncol (Dordr). 2020. PMID: 32623699
Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis.
Zeng X, Zhou J, Xiong Z, Sun H, Yang W, Mok MTS, Wang J, Li J, Liu M, Tang W, Feng Y, Wang HK, Tsang SW, Chow KL, Yeung PC, Wong J, Lai PB, Chan AW, To KF, Chan SL, Xia Q, Xue J, Chen X, Yu J, Peng S, Sung JJ, Kuang M, Cheng AS. Zeng X, et al. Among authors: cheng as. Cell Mol Immunol. 2021 Apr;18(4):1005-1015. doi: 10.1038/s41423-020-00534-2. Epub 2020 Sep 2. Cell Mol Immunol. 2021. PMID: 32879468 Free PMC article.
Proton pump inhibitor pantoprazole abrogates adriamycin-resistant gastric cancer cell invasiveness via suppression of Akt/GSK-β/β-catenin signaling and epithelial-mesenchymal transition.
Zhang B, Yang Y, Shi X, Liao W, Chen M, Cheng AS, Yan H, Fang C, Zhang S, Xu G, Shen S, Huang S, Chen G, Lv Y, Ling T, Zhang X, Wang L, Zhuge Y, Zou X. Zhang B, et al. Among authors: cheng as. Cancer Lett. 2015 Jan 28;356(2 Pt B):704-12. doi: 10.1016/j.canlet.2014.10.016. Epub 2014 Oct 23. Cancer Lett. 2015. PMID: 25449432
381 results