Du F - Search Results

1

Synthesis and biological evaluation of benzocyclobutane-C-glycosides as potent and orally active SGLT1/SGLT2 dual inhibitors.

Kuo GH, Gaul MD, Liang Y, Xu JZ, Du F, Hornby P, Xu G, Qi J, Wallace N, Lee S, Grant E, Murray WV, Demarest K. Kuo GH, et al. Among authors: du f. Bioorg Med Chem Lett. 2018 Apr 15;28(7):1182-1187. doi: 10.1016/j.bmcl.2018.02.057. Epub 2018 Mar 1. Bioorg Med Chem Lett. 2018. PMID: 29523385

2

Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile.

Semple G, Lehmann J, Wong A, Ren A, Bruce M, Shin YJ, Sage CR, Morgan M, Chen WC, Sebring K, Chu ZL, Leonard JN, Al-Shamma H, Grottick AJ, Du F, Liang Y, Demarest K, Jones RM. Semple G, et al. Among authors: du f. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1750-5. doi: 10.1016/j.bmcl.2011.12.092. Epub 2011 Dec 30. Bioorg Med Chem Lett. 2012. PMID: 22264481

3

Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models.

Liang Y, Arakawa K, Ueta K, Matsushita Y, Kuriyama C, Martin T, Du F, Liu Y, Xu J, Conway B, Conway J, Polidori D, Ways K, Demarest K. Liang Y, et al. Among authors: du f. PLoS One. 2012;7(2):e30555. doi: 10.1371/journal.pone.0030555. Epub 2012 Feb 15. PLoS One. 2012. PMID: 22355316 Free PMC article.

4

Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo.

Qi J, Lang W, Connelly MA, Du F, Liang Y, Caldwell GW, Martin T, Hansen MK, Kuo GH, Gaul MD, Pocai A, Lee S. Qi J, et al. Among authors: du f. Anal Biochem. 2017 May 1;524:68-75. doi: 10.1016/j.ab.2016.09.017. Epub 2016 Sep 22. Anal Biochem. 2017. PMID: 27665677

5

Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists.

Zhang X, Sui Z, Kauffman J, Hou C, Chen C, Du F, Kirchner T, Liang Y, Johnson D, Murray WV, Demarest K. Zhang X, et al. Among authors: du f. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1760-1764. doi: 10.1016/j.bmcl.2017.02.069. Epub 2017 Feb 28. Bioorg Med Chem Lett. 2017. PMID: 28285911

6

Discovery of Orally Efficacious Tetrahydrobenzimidazoles as TGR5 Agonists for Type 2 Diabetes.

Zhang X, Wall M, Sui Z, Kauffman J, Hou C, Chen C, Du F, Kirchner T, Liang Y, Johnson DL, Murray WV, Demarest K. Zhang X, et al. Among authors: du f. ACS Med Chem Lett. 2017 Apr 21;8(5):560-565. doi: 10.1021/acsmedchemlett.7b00116. eCollection 2017 May 11. ACS Med Chem Lett. 2017. PMID: 28523111 Free PMC article.

7

Potent Sodium/Glucose Cotransporter SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents.

Du F, Hinke SA, Cavanaugh C, Polidori D, Wallace N, Kirchner T, Jennis M, Lang W, Kuo GH, Gaul MD, Lenhard J, Demarest K, Ajami NJ, Liang Y, Hornby PJ. Du F, et al. J Pharmacol Exp Ther. 2018 Jun;365(3):676-687. doi: 10.1124/jpet.118.248575. Epub 2018 Apr 19. J Pharmacol Exp Ther. 2018. PMID: 29674332

8

Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors.

Xu G, Gaul MD, Kuo GH, Du F, Xu JZ, Wallace N, Hinke S, Kirchner T, Silva J, Huebert ND, Lee S, Murray W, Liang Y, Demarest K. Xu G, et al. Among authors: du f. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3446-3453. doi: 10.1016/j.bmcl.2018.09.025. Epub 2018 Sep 19. Bioorg Med Chem Lett. 2018. PMID: 30268701

9

Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes.

Xu G, Gaul MD, Song F, Du F, Liang Y, DesJarlais RL, DiLoreto K, Shook B, Rentzeperis D, Santulli R, Eckardt A, Demarest K. Xu G, et al. Among authors: du f. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126668. doi: 10.1016/j.bmcl.2019.126668. Epub 2019 Sep 4. Bioorg Med Chem Lett. 2019. PMID: 31519374

10

5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors.

Xu G, Du F, Kuo GH, Xu JZ, Liang Y, Demarest K, Gaul MD. Xu G, et al. Among authors: du f. Bioorg Med Chem Lett. 2020 Sep 1;30(17):127387. doi: 10.1016/j.bmcl.2020.127387. Epub 2020 Jul 5. Bioorg Med Chem Lett. 2020. PMID: 32738984

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