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MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity.
Branigan TB, Kozono D, Schade AE, Deraska P, Rivas HG, Sambel L, Reavis HD, Shapiro GI, D'Andrea AD, DeCaprio JA. Branigan TB, et al. Among authors: reavis hd. Cell Rep. 2021 Mar 2;34(9):108808. doi: 10.1016/j.celrep.2021.108808. Cell Rep. 2021. PMID: 33657372 Free PMC article.
The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP Inhibition.
Parmar K, Kochupurakkal BS, Lazaro JB, Wang ZC, Palakurthi S, Kirschmeier PT, Yang C, Sambel LA, Färkkilä A, Reznichenko E, Reavis HD, Dunn CE, Zou L, Do KT, Konstantinopoulos PA, Matulonis UA, Liu JF, D'Andrea AD, Shapiro GI. Parmar K, et al. Among authors: reavis hd. Clin Cancer Res. 2019 Oct 15;25(20):6127-6140. doi: 10.1158/1078-0432.CCR-19-0448. Epub 2019 Aug 13. Clin Cancer Res. 2019. PMID: 31409614 Free PMC article.
Tumor Innervation: Cancer Has Some Nerve.
Reavis HD, Chen HI, Drapkin R. Reavis HD, et al. Trends Cancer. 2020 Dec;6(12):1059-1067. doi: 10.1016/j.trecan.2020.07.005. Epub 2020 Aug 14. Trends Cancer. 2020. PMID: 32807693 Free PMC article. Review.