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The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1.
Perez Carrion M, Pischedda F, Biosa A, Russo I, Straniero L, Civiero L, Guida M, Gloeckner CJ, Ticozzi N, Tiloca C, Mariani C, Pezzoli G, Duga S, Pichler I, Pan L, Landers JE, Greggio E, Hess MW, Goldwurm S, Piccoli G. Perez Carrion M, et al. Among authors: pan l. Front Mol Neurosci. 2018 Feb 28;11:64. doi: 10.3389/fnmol.2018.00064. eCollection 2018. Front Mol Neurosci. 2018. PMID: 29541021 Free PMC article.
Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain.
Piccoli G, Onofri F, Cirnaru MD, Kaiser CJ, Jagtap P, Kastenmüller A, Pischedda F, Marte A, von Zweydorf F, Vogt A, Giesert F, Pan L, Antonucci F, Kiel C, Zhang M, Weinkauf S, Sattler M, Sala C, Matteoli M, Ueffing M, Gloeckner CJ. Piccoli G, et al. Among authors: pan l. Mol Cell Biol. 2014 Jun;34(12):2147-61. doi: 10.1128/MCB.00914-13. Epub 2014 Mar 31. Mol Cell Biol. 2014. PMID: 24687852 Free PMC article.
LRRK2 G2019S kinase activity triggers neurotoxic NSF aggregation.
Pischedda F, Cirnaru MD, Ponzoni L, Sandre M, Biosa A, Carrion MP, Marin O, Morari M, Pan L, Greggio E, Bandopadhyay R, Sala M, Piccoli G. Pischedda F, et al. Among authors: pan l. Brain. 2021 Jun 22;144(5):1509-1525. doi: 10.1093/brain/awab073. Brain. 2021. PMID: 33876242
SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination.
Wei R, Xu LW, Liu J, Li Y, Zhang P, Shan B, Lu X, Qian L, Wu Z, Dong K, Zhu H, Pan L, Yuan J, Pan H. Wei R, et al. Among authors: pan l, pan h. Genes Dev. 2017 Jun 1;31(11):1162-1176. doi: 10.1101/gad.299776.117. Epub 2017 Jul 12. Genes Dev. 2017. PMID: 28701375 Free PMC article.
8,559 results