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The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase.
Mori G, Orena BS, Franch C, Mitchenall LA, Godbole AA, Rodrigues L, Aguilar-Pérez C, Zemanová J, Huszár S, Forbak M, Lane TR, Sabbah M, Deboosere N, Frita R, Vandeputte A, Hoffmann E, Russo R, Connell N, Veilleux C, Jha RK, Kumar P, Freundlich JS, Brodin P, Aínsa JA, Nagaraja V, Maxwell A, Mikušová K, Pasca MR, Ekins S. Mori G, et al. Among authors: rodrigues l. Tuberculosis (Edinb). 2018 Sep;112:98-109. doi: 10.1016/j.tube.2018.08.004. Epub 2018 Aug 11. Tuberculosis (Edinb). 2018. PMID: 30205975
Measuring Efflux and Permeability in Mycobacteria.
Rodrigues L, Aínsa JA, Viveiros M. Rodrigues L, et al. Methods Mol Biol. 2021;2314:231-245. doi: 10.1007/978-1-0716-1460-0_9. Methods Mol Biol. 2021. PMID: 34235655
Antituberculosis drugs: reducing efflux=increasing activity.
Rodrigues L, Parish T, Balganesh M, Ainsa JA. Rodrigues L, et al. Drug Discov Today. 2017 Mar;22(3):592-599. doi: 10.1016/j.drudis.2017.01.002. Epub 2017 Jan 13. Drug Discov Today. 2017. PMID: 28089787 Review.
Measuring efflux and permeability in mycobacteria.
Rodrigues L, Viveiros M, Aínsa JA. Rodrigues L, et al. Methods Mol Biol. 2015;1285:227-39. doi: 10.1007/978-1-4939-2450-9_13. Methods Mol Biol. 2015. PMID: 25779319
Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria.
Singh V, Dhar N, Pató J, Kolly GS, Korduláková J, Forbak M, Evans JC, Székely R, Rybniker J, Palčeková Z, Zemanová J, Santi I, Signorino-Gelo F, Rodrigues L, Vocat A, Covarrubias AS, Rengifo MG, Johnsson K, Mowbray S, Buechler J, Delorme V, Brodin P, Knott GW, Aínsa JA, Warner DF, Kéri G, Mikušová K, McKinney JD, Cole ST, Mizrahi V, Hartkoorn RC. Singh V, et al. Among authors: rodrigues l. Mol Microbiol. 2017 Jan;103(1):13-25. doi: 10.1111/mmi.13535. Epub 2016 Oct 29. Mol Microbiol. 2017. PMID: 27677649 Free article.
Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against Helicobacter pylori Drug-Resistant Clinical Strains and in Helicobacter pylori-Infected Mice.
Salillas S, Alías M, Michel V, Mahía A, Lucía A, Rodrigues L, Bueno J, Galano-Frutos JJ, De Reuse H, Velázquez-Campoy A, Carrodeguas JA, Sostres C, Castillo J, Aínsa JA, Díaz-de-Villegas MD, Lanas Á, Touati E, Sancho J. Salillas S, et al. Among authors: rodrigues l. J Med Chem. 2019 Jul 11;62(13):6102-6115. doi: 10.1021/acs.jmedchem.9b00355. Epub 2019 Jun 21. J Med Chem. 2019. PMID: 31244111 Free article.
2,770 results