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An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.
Ferrer CM, Alders M, Postma AV, Park S, Klein MA, Cetinbas M, Pajkrt E, Glas A, van Koningsbruggen S, Christoffels VM, Mannens MMAM, Knegt L, Etchegaray JP, Sadreyev RI, Denu JM, Mostoslavsky G, van Maarle MC, Mostoslavsky R. Ferrer CM, et al. Among authors: denu jm. Genes Dev. 2018 Mar 1;32(5-6):373-388. doi: 10.1101/gad.307330.117. Epub 2018 Mar 19. Genes Dev. 2018. PMID: 29555651 Free PMC article.
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.
Dominy JE Jr, Lee Y, Jedrychowski MP, Chim H, Jurczak MJ, Camporez JP, Ruan HB, Feldman J, Pierce K, Mostoslavsky R, Denu JM, Clish CB, Yang X, Shulman GI, Gygi SP, Puigserver P. Dominy JE Jr, et al. Among authors: denu jm. Mol Cell. 2012 Dec 28;48(6):900-13. doi: 10.1016/j.molcel.2012.09.030. Epub 2012 Nov 8. Mol Cell. 2012. PMID: 23142079 Free PMC article.
Mechanism of activation for the sirtuin 6 protein deacylase.
Klein MA, Liu C, Kuznetsov VI, Feltenberger JB, Tang W, Denu JM. Klein MA, et al. Among authors: denu jm. J Biol Chem. 2020 Jan 31;295(5):1385-1399. doi: 10.1074/jbc.RA119.011285. Epub 2019 Dec 10. J Biol Chem. 2020. PMID: 31822559 Free PMC article.
Sirt6 regulates lifespan in Drosophila melanogaster.
Taylor JR, Wood JG, Mizerak E, Hinthorn S, Liu J, Finn M, Gordon S, Zingas L, Chang C, Klein MA, Denu JM, Gorbunova V, Seluanov A, Boeke JD, Sedivy JM, Helfand SL. Taylor JR, et al. Among authors: denu jm. Proc Natl Acad Sci U S A. 2022 Feb 1;119(5):e2111176119. doi: 10.1073/pnas.2111176119. Proc Natl Acad Sci U S A. 2022. PMID: 35091469 Free PMC article.
Linking SIRT2 to Parkinson's disease.
Garske AL, Smith BC, Denu JM. Garske AL, et al. Among authors: denu jm. ACS Chem Biol. 2007 Aug 17;2(8):529-32. doi: 10.1021/cb700160d. ACS Chem Biol. 2007. PMID: 17708669
207 results