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Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging.
Jin Y, Takeda Y, Kondo Y, Tripathi LP, Kang S, Takeshita H, Kuhara H, Maeda Y, Higashiguchi M, Miyake K, Morimura O, Koba T, Hayama Y, Koyama S, Nakanishi K, Iwasaki T, Tetsumoto S, Tsujino K, Kuroyama M, Iwahori K, Hirata H, Takimoto T, Suzuki M, Nagatomo I, Sugimoto K, Fujii Y, Kida H, Mizuguchi K, Ito M, Kijima T, Rakugi H, Mekada E, Tachibana I, Kumanogoh A. Jin Y, et al. Among authors: takeshita h. Sci Rep. 2018 Mar 23;8(1):5145. doi: 10.1038/s41598-018-23338-x. Sci Rep. 2018. PMID: 29572511 Free PMC article.
Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.
Yamamoto K, Kakino A, Takeshita H, Hayashi N, Li L, Nakano A, Hanasaki-Yamamoto H, Fujita Y, Imaizumi Y, Toyama-Yokoyama S, Nakama C, Kawai T, Takeda M, Hongyo K, Oguro R, Maekawa Y, Itoh N, Takami Y, Onishi M, Takeya Y, Sugimoto K, Kamide K, Nakagami H, Ohishi M, Kurtz TW, Sawamura T, Rakugi H. Yamamoto K, et al. Among authors: takeshita h. FASEB J. 2015 Aug;29(8):3342-56. doi: 10.1096/fj.15-271627. Epub 2015 Apr 15. FASEB J. 2015. PMID: 25877213
Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice.
Takeshita H, Yamamoto K, Nozato S, Takeda M, Fukada SI, Inagaki T, Tsuchimochi H, Shirai M, Nozato Y, Fujimoto T, Imaizumi Y, Yokoyama S, Nagasawa M, Hamano G, Hongyo K, Kawai T, Hanasaki-Yamamoto H, Takeda S, Takahashi T, Akasaka H, Itoh N, Takami Y, Takeya Y, Sugimoto K, Nakagami H, Rakugi H. Takeshita H, et al. J Cachexia Sarcopenia Muscle. 2018 Oct;9(5):975-986. doi: 10.1002/jcsm.12334. Epub 2018 Sep 11. J Cachexia Sarcopenia Muscle. 2018. PMID: 30207087 Free PMC article.
Pathophysiological significance of cylindromatosis in the vascular endothelium and macrophages for the initiation of age-related atherogenesis.
Imaizumi Y, Takami Y, Yamamoto K, Nagasawa M, Nozato Y, Nozato S, Takeshita H, Wang C, Yokoyama S, Hayashi H, Hongyo K, Akasaka H, Takeya Y, Sugimoto K, Nakagami H, Rakugi H. Imaizumi Y, et al. Among authors: takeshita h. Biochem Biophys Res Commun. 2019 Jan 22;508(4):1168-1174. doi: 10.1016/j.bbrc.2018.12.025. Epub 2018 Dec 13. Biochem Biophys Res Commun. 2019. PMID: 30554661
Angiotensin 1-7 alleviates aging-associated muscle weakness and bone loss, but is not associated with accelerated aging in ACE2-knockout mice.
Nozato S, Yamamoto K, Takeshita H, Nozato Y, Imaizumi Y, Fujimoto T, Yokoyama S, Nagasawa M, Takeda M, Hongyo K, Akasaka H, Takami Y, Takeya Y, Sugimoto K, Mogi M, Horiuchi M, Rakugi H. Nozato S, et al. Among authors: takeshita h. Clin Sci (Lond). 2019 Sep 24;133(18):2005-2018. doi: 10.1042/CS20190573. Print 2019 Sep 30. Clin Sci (Lond). 2019. PMID: 31519791
858 results