Chan HTC - Search Results

1

Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies.

Yu X, Chan HTC, Orr CM, Dadas O, Booth SG, Dahal LN, Penfold CA, O'Brien L, Mockridge CI, French RR, Duriez P, Douglas LR, Pearson AR, Cragg MS, Tews I, Glennie MJ, White AL. Yu X, et al. Among authors: chan htc. Cancer Cell. 2018 Apr 9;33(4):664-675.e4. doi: 10.1016/j.ccell.2018.02.009. Epub 2018 Mar 22. Cancer Cell. 2018. PMID: 29576376 Free PMC article.

2

The development of anti-CD79 monoclonal antibodies for treatment of B-cell neoplastic disease.

Zhang L, French RR, Chan HT, O'Keefe TL, Cragg MS, Power MJ, Glennie MJ. Zhang L, et al. Ther Immunol. 1995 Aug;2(4):191-202. Ther Immunol. 1995. PMID: 9358611

3

CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help.

French RR, Chan HT, Tutt AL, Glennie MJ. French RR, et al. Nat Med. 1999 May;5(5):548-53. doi: 10.1038/8426. Nat Med. 1999. PMID: 10229232

4

The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signaling for apoptosis.

Cragg MS, Chan HT, Fox MD, Tutt A, Smith A, Oscier DG, Hamblin TJ, Glennie MJ. Cragg MS, et al. Blood. 2002 Nov 1;100(9):3068-76. doi: 10.1182/blood.V100.9.3068. Blood. 2002. PMID: 12384401 Free article.

5

Complement-mediated lysis by anti-CD20 mAb correlates with segregation into lipid rafts.

Cragg MS, Morgan SM, Chan HT, Morgan BP, Filatov AV, Johnson PW, French RR, Glennie MJ. Cragg MS, et al. Blood. 2003 Feb 1;101(3):1045-52. doi: 10.1182/blood-2002-06-1761. Epub 2002 Sep 19. Blood. 2003. PMID: 12393541 Free article.

6

Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses.

Taraban VY, Rowley TF, O'Brien L, Chan HT, Haswell LE, Green MH, Tutt AL, Glennie MJ, Al-Shamkhani A. Taraban VY, et al. Eur J Immunol. 2002 Dec;32(12):3617-27. doi: 10.1002/1521-4141(200212)32:12<3617::AID-IMMU3617>3.0.CO;2-M. Eur J Immunol. 2002. PMID: 12516549 Free article.

7

CD20-induced lymphoma cell death is independent of both caspases and its redistribution into triton X-100 insoluble membrane rafts.

Chan HT, Hughes D, French RR, Tutt AL, Walshe CA, Teeling JL, Glennie MJ, Cragg MS. Chan HT, et al. Cancer Res. 2003 Sep 1;63(17):5480-9. Cancer Res. 2003. PMID: 14500384

8

Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection.

Beers SA, French RR, Chan HT, Lim SH, Jarrett TC, Vidal RM, Wijayaweera SS, Dixon SV, Kim H, Cox KL, Kerr JP, Johnston DA, Johnson PW, Verbeek JS, Glennie MJ, Cragg MS. Beers SA, et al. Blood. 2010 Jun 24;115(25):5191-201. doi: 10.1182/blood-2010-01-263533. Epub 2010 Mar 11. Blood. 2010. PMID: 20223920 Free article.

9

Interaction with FcγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody.

White AL, Chan HT, Roghanian A, French RR, Mockridge CI, Tutt AL, Dixon SV, Ajona D, Verbeek JS, Al-Shamkhani A, Cragg MS, Beers SA, Glennie MJ. White AL, et al. J Immunol. 2011 Aug 15;187(4):1754-63. doi: 10.4049/jimmunol.1101135. Epub 2011 Jul 8. J Immunol. 2011. PMID: 21742972

10

Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy.

Lim SH, Vaughan AT, Ashton-Key M, Williams EL, Dixon SV, Chan HT, Beers SA, French RR, Cox KL, Davies AJ, Potter KN, Mockridge CI, Oscier DG, Johnson PW, Cragg MS, Glennie MJ. Lim SH, et al. Blood. 2011 Sep 1;118(9):2530-40. doi: 10.1182/blood-2011-01-330357. Epub 2011 Jul 18. Blood. 2011. PMID: 21768293 Free article.

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