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Accurate detection and quantification of epigenetic and genetic second hits in BRCA1 and BRCA2-associated hereditary breast and ovarian cancer reveals multiple co-acting second hits.
Van Heetvelde M, Van Bockstal M, Poppe B, Lambein K, Rosseel T, Atanesyan L, Deforce D, Van Den Berghe I, De Leeneer K, Van Dorpe J, Vral A, Claes KBM. Van Heetvelde M, et al. Among authors: vral a. Cancer Lett. 2018 Jul 1;425:125-133. doi: 10.1016/j.canlet.2018.03.026. Epub 2018 Mar 23. Cancer Lett. 2018. PMID: 29580810
BRCA1, BRCA2 and PALB2 mutations and CHEK2 c.1100delC in different South African ethnic groups diagnosed with premenopausal and/or triple negative breast cancer.
Francies FZ, Wainstein T, De Leeneer K, Cairns A, Murdoch M, Nietz S, Cubasch H, Poppe B, Van Maerken T, Crombez B, Coene I, Kerr R, Slabbert JP, Vral A, Krause A, Baeyens A, Claes KB. Francies FZ, et al. Among authors: vral a. BMC Cancer. 2015 Nov 17;15:912. doi: 10.1186/s12885-015-1913-6. BMC Cancer. 2015. PMID: 26577449 Free PMC article.
Thorough in silico and in vitro cDNA analysis of 21 putative BRCA1 and BRCA2 splice variants and a complex tandem duplication in BRCA2 allowing the identification of activated cryptic splice donor sites in BRCA2 exon 11.
Baert A, Machackova E, Coene I, Cremin C, Turner K, Portigal-Todd C, Asrat MJ, Nuk J, Mindlin A, Young S, MacMillan A, Van Maerken T, Trbusek M, McKinnon W, Wood ME, Foulkes WD, Santamariña M, de la Hoya M, Foretova L, Poppe B, Vral A, Rosseel T, De Leeneer K, Vega A, Claes KBM. Baert A, et al. Among authors: vral a. Hum Mutat. 2018 Apr;39(4):515-526. doi: 10.1002/humu.23390. Epub 2018 Jan 22. Hum Mutat. 2018. PMID: 29280214
Chromosomal radiosensitivity of triple negative breast cancer patients.
Francies FZ, Herd O, Cairns A, Nietz S, Murdoch M, Slabbert J, Claes KBM, Vral A, Baeyens A. Francies FZ, et al. Among authors: vral a. Int J Radiat Biol. 2019 Nov;95(11):1507-1516. doi: 10.1080/09553002.2019.1649502. Epub 2019 Aug 12. Int J Radiat Biol. 2019. PMID: 31348739
159 results