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EphA2 receptor is a key player in the metastatic onset of Ewing sarcoma.
Garcia-Monclús S, López-Alemany R, Almacellas-Rabaiget O, Herrero-Martín D, Huertas-Martinez J, Lagares-Tena L, Alba-Pavón P, Hontecillas-Prieto L, Mora J, de Álava E, Rello-Varona S, Giangrande PH, Tirado OM. Garcia-Monclús S, et al. Int J Cancer. 2018 Sep 1;143(5):1188-1201. doi: 10.1002/ijc.31405. Epub 2018 Apr 16. Int J Cancer. 2018. PMID: 29582409 Free PMC article.
RING1B contributes to Ewing sarcoma development by repressing the NaV1.6 sodium channel and the NF-κB pathway, independently of the fusion oncoprotein.
Hernandez-Muñoz I, Figuerola E, Sanchez-Molina S, Rodriguez E, Fernández-Mariño AI, Pardo-Pastor C, Bahamonde MI, Fernández-Fernández JM, García-Domínguez DJ, Hontecillas-Prieto L, Lavarino C, Carcaboso AM, de Torres C, Tirado OM, de Alava E, Mora J. Hernandez-Muñoz I, et al. Oncotarget. 2016 Jul 19;7(29):46283-46300. doi: 10.18632/oncotarget.10092. Oncotarget. 2016. PMID: 27317769 Free PMC article.
DNA methylation profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with caveolin-1.
Huertas-Martínez J, Court F, Rello-Varona S, Herrero-Martín D, Almacellas-Rabaiget O, Sáinz-Jaspeado M, Garcia-Monclús S, Lagares-Tena L, Buj R, Hontecillas-Prieto L, Sastre A, Azorin D, Sanjuan X, López-Alemany R, Moran S, Roma J, Gallego S, Mora J, García Del Muro X, Giangrande PH, Peinado MA, Alonso J, de Alava E, Monk D, Esteller M, Tirado OM. Huertas-Martínez J, et al. Cancer Lett. 2017 Feb 1;386:196-207. doi: 10.1016/j.canlet.2016.11.020. Epub 2016 Nov 25. Cancer Lett. 2017. PMID: 27894957
The combination of epigenetic drugs SAHA and HCI-2509 synergistically inhibits EWS-FLI1 and tumor growth in Ewing sarcoma.
García-Domínguez DJ, Hontecillas-Prieto L, Rodríguez-Núñez P, Pascual-Pasto G, Vila-Ubach M, García-Mejías R, Robles MJ, Tirado OM, Mora J, Carcaboso AM, de Álava E. García-Domínguez DJ, et al. Oncotarget. 2018 Jul 31;9(59):31397-31410. doi: 10.18632/oncotarget.25829. eCollection 2018 Jul 31. Oncotarget. 2018. PMID: 30140378 Free PMC article.
Treatment-driven selection of chemoresistant Ewing sarcoma tumors with limited drug distribution.
Castillo-Ecija H, Monterrubio C, Pascual-Pasto G, Gomez-Gonzalez S, Garcia-Dominguez DJ, Hontecillas-Prieto L, Resa-Pares C, Burgueño V, Paco S, Olaciregui NG, Vila-Ubach M, Restrepo-Perdomo C, Cuadrado-Vilanova M, Balaguer-Lluna L, Perez-Jaume S, Castañeda A, Santa-Maria V, Roldan M, Suñol M, de Alava E, Mora J, Lavarino C, Carcaboso AM. Castillo-Ecija H, et al. J Control Release. 2020 Aug 10;324:440-449. doi: 10.1016/j.jconrel.2020.05.032. Epub 2020 Jun 1. J Control Release. 2020. PMID: 32497782
Stromal SNAI2 Is Required for ERBB2 Breast Cancer Progression.
Blanco-Gómez A, Hontecillas-Prieto L, Corchado-Cobos R, García-Sancha N, Salvador N, Castellanos-Martín A, Sáez-Freire MDM, Mendiburu-Eliçabe M, Alonso-López D, De Las Rivas J, Lorente M, García-Casas A, Del Carmen S, Abad-Hernández MDM, Cruz-Hernández JJ, Rodríguez-Sánchez CA, Claros-Ampuero J, García-Cenador B, García-Criado J, Orimo A, Gridley T, Pérez-Losada J, Castillo-Lluva S. Blanco-Gómez A, et al. Cancer Res. 2020 Dec 1;80(23):5216-5230. doi: 10.1158/0008-5472.CAN-20-0278. Epub 2020 Oct 6. Cancer Res. 2020. PMID: 33023950 Free PMC article.
34 results