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EPHX1 rs1051740 T>C (Tyr113His) is strongly associated with acute myeloid leukemia and KMT2A rearrangements in early age.
Brisson GD, de Almeida Lopes B, Andrade FG, Dos Santos Bueno FV, Sardou-Cezar I, de Aguiar Gonçalves BA, Terra-Granado E, Paraguassú-Braga FH, Pombo-de-Oliveira MS. Brisson GD, et al. Among authors: de aguiar goncalves ba. Arch Toxicol. 2018 Jun;92(6):2001-2012. doi: 10.1007/s00204-018-2198-8. Epub 2018 Mar 31. Arch Toxicol. 2018. PMID: 29605894
NQO1 rs1800566 (C609T), PON1 rs662 (Q192R), and PON1 rs854560 (L55M) polymorphisms segregate the risk of childhood acute leukemias according to age range distribution.
de Aguiar Gonçalves BA, Vasconcelos GM, Thuler LC, Andrade C, Faro A, Pombo-de-Oliveira MS; Brazilian Collaborative Study Group of Infant Acute Leukemia; Emerenciano M, de Camargo B, Bernstain L, Neves CC, Agareno JM, de Carvalho LM, Araújo FN, de Brito NP, Magalhães IQ, Cordoba JC, Pimenta F, Gadelha A, Cartaxo E, Basegio RM, Mnayarji A, Souza MS, Arencibia A, Melaragno R, Cóser VM, Lafayete TC, Koifman S. de Aguiar Gonçalves BA, et al. Cancer Causes Control. 2012 Nov;23(11):1811-9. doi: 10.1007/s10552-012-0060-5. Epub 2012 Sep 14. Cancer Causes Control. 2012. PMID: 22976839