Wienert B - Search Results

1

Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding.

Martyn GE, Wienert B, Yang L, Shah M, Norton LJ, Burdach J, Kurita R, Nakamura Y, Pearson RCM, Funnell APW, Quinlan KGR, Crossley M. Martyn GE, et al. Among authors: wienert b. Nat Genet. 2018 Apr;50(4):498-503. doi: 10.1038/s41588-018-0085-0. Epub 2018 Apr 2. Nat Genet. 2018. PMID: 29610478

2

Differential regulation of the α-globin locus by Krüppel-like Factor 3 in erythroid and non-erythroid cells.

Funnell AP, Vernimmen D, Lim WF, Mak KS, Wienert B, Martyn GE, Artuz CM, Burdach J, Quinlan KG, Higgs DR, Whitelaw E, Pearson RC, Crossley M. Funnell AP, et al. Among authors: wienert b. BMC Mol Biol. 2014 May 16;15:8. doi: 10.1186/1471-2199-15-8. BMC Mol Biol. 2014. PMID: 24885809 Free PMC article.

3

Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.

Wienert B, Funnell AP, Norton LJ, Pearson RC, Wilkinson-White LE, Lester K, Vadolas J, Porteus MH, Matthews JM, Quinlan KG, Crossley M. Wienert B, et al. Nat Commun. 2015 May 14;6:7085. doi: 10.1038/ncomms8085. Nat Commun. 2015. PMID: 25971621 Free article.

4

KLF1 drives the expression of fetal hemoglobin in British HPFH.

Wienert B, Martyn GE, Kurita R, Nakamura Y, Quinlan KGR, Crossley M. Wienert B, et al. Blood. 2017 Aug 10;130(6):803-807. doi: 10.1182/blood-2017-02-767400. Epub 2017 Jun 28. Blood. 2017. PMID: 28659276 Free article.

5

KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells.

Norton LJ, Funnell APW, Burdach J, Wienert B, Kurita R, Nakamura Y, Philipsen S, Pearson RCM, Quinlan KGR, Crossley M. Norton LJ, et al. Among authors: wienert b. Blood Adv. 2017 Apr 25;1(11):685-692. doi: 10.1182/bloodadvances.2016002303. eCollection 2017 Apr 25. Blood Adv. 2017. PMID: 29296711 Free PMC article.

6

Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies.

Wienert B, Martyn GE, Funnell APW, Quinlan KGR, Crossley M. Wienert B, et al. Trends Genet. 2018 Dec;34(12):927-940. doi: 10.1016/j.tig.2018.09.004. Epub 2018 Oct 1. Trends Genet. 2018. PMID: 30287096 Review.

7

A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site.

Martyn GE, Wienert B, Kurita R, Nakamura Y, Quinlan KGR, Crossley M. Martyn GE, et al. Among authors: wienert b. Blood. 2019 Feb 21;133(8):852-856. doi: 10.1182/blood-2018-07-863951. Epub 2019 Jan 7. Blood. 2019. PMID: 30617196 Free article.

8

Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor.

Burdach J, Funnell AP, Mak KS, Artuz CM, Wienert B, Lim WF, Tan LY, Pearson RC, Crossley M. Burdach J, et al. Among authors: wienert b. Nucleic Acids Res. 2014 Jan;42(1):276-89. doi: 10.1093/nar/gkt895. Epub 2013 Oct 7. Nucleic Acids Res. 2014. PMID: 24106088 Free PMC article.

9

Phosphorylation of Krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomain-interacting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity.

Dewi V, Kwok A, Lee S, Lee MM, Tan YM, Nicholas HR, Isono K, Wienert B, Mak KS, Knights AJ, Quinlan KG, Cordwell SJ, Funnell AP, Pearson RC, Crossley M. Dewi V, et al. Among authors: wienert b. J Biol Chem. 2015 Mar 27;290(13):8591-605. doi: 10.1074/jbc.M115.638338. Epub 2015 Feb 6. J Biol Chem. 2015. PMID: 25659434 Free PMC article.

10

Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin.

Ravi NS, Wienert B, Wyman SK, Bell HW, George A, Mahalingam G, Vu JT, Prasad K, Bandlamudi BP, Devaraju N, Rajendiran V, Syedbasha N, Pai AA, Nakamura Y, Kurita R, Narayanasamy M, Balasubramanian P, Thangavel S, Marepally S, Velayudhan SR, Srivastava A, DeWitt MA, Crossley M, Corn JE, Mohankumar KM. Ravi NS, et al. Among authors: wienert b. Elife. 2022 Feb 11;11:e65421. doi: 10.7554/eLife.65421. Elife. 2022. PMID: 35147495 Free PMC article.

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