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Page 1
Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation.
Vogl T, Stratis A, Wixler V, Völler T, Thurainayagam S, Jorch SK, Zenker S, Dreiling A, Chakraborty D, Fröhling M, Paruzel P, Wehmeyer C, Hermann S, Papantonopoulou O, Geyer C, Loser K, Schäfers M, Ludwig S, Stoll M, Leanderson T, Schultze JL, König S, Pap T, Roth J. Vogl T, et al. Among authors: paruzel p. J Clin Invest. 2018 May 1;128(5):1852-1866. doi: 10.1172/JCI89867. Epub 2018 Apr 3. J Clin Invest. 2018. PMID: 29611822 Free PMC article.
Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction.
Wehmeyer C, Frank S, Beckmann D, Böttcher M, Cromme C, König U, Fennen M, Held A, Paruzel P, Hartmann C, Stratis A, Korb-Pap A, Kamradt T, Kramer I, van den Berg W, Kneissel M, Pap T, Dankbar B. Wehmeyer C, et al. Among authors: paruzel p. Sci Transl Med. 2016 Mar 16;8(330):330ra35. doi: 10.1126/scitranslmed.aac4351. Epub 2016 Mar 16. Sci Transl Med. 2016. PMID: 27089204
Deletion of activin A in mesenchymal but not myeloid cells ameliorates disease severity in experimental arthritis.
Waltereit-Kracke V, Wehmeyer C, Beckmann D, Werbenko E, Reinhardt J, Geers F, Dienstbier M, Fennen M, Intemann J, Paruzel P, Korb-Pap A, Pap T, Dankbar B. Waltereit-Kracke V, et al. Among authors: paruzel p. Ann Rheum Dis. 2022 Aug;81(8):1106-1118. doi: 10.1136/annrheumdis-2021-221409. Epub 2022 Apr 13. Ann Rheum Dis. 2022. PMID: 35418478 Free PMC article.
TRPC1 links calcium signaling to cellular senescence in the protection against post-traumatic osteoarthritis.
Sambale M, Lively S, Espin-Garcia O, Potla P, Pastrello C, Bödecker S, Wessendorf L, Kleimann S, Paruzel P, Asgarian R, Tosun A, Intemann J, Bertrand J, Dell'Accio F, Kapoor M, Pap T, Sherwood J. Sambale M, et al. Among authors: paruzel p. JCI Insight. 2024 Dec 24:e182103. doi: 10.1172/jci.insight.182103. Online ahead of print. JCI Insight. 2024. PMID: 39718827 Free article.