Polyzos AA - Search Results

1

XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent.

Polyzos AA, Wood NI, Williams P, Wipf P, Morton AJ, McMurray CT. Polyzos AA, et al. PLoS One. 2018 Apr 9;13(4):e0194580. doi: 10.1371/journal.pone.0194580. eCollection 2018. PLoS One. 2018. PMID: 29630611 Free PMC article.

2

Mitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes.

Polyzos A, Holt A, Brown C, Cosme C, Wipf P, Gomez-Marin A, Castro MR, Ayala-Peña S, McMurray CT. Polyzos A, et al. Hum Mol Genet. 2016 May 1;25(9):1792-802. doi: 10.1093/hmg/ddw051. Epub 2016 Feb 21. Hum Mol Genet. 2016. PMID: 26908614 Free PMC article.

3

The chicken or the egg: mitochondrial dysfunction as a cause or consequence of toxicity in Huntington's disease.

Polyzos AA, McMurray CT. Polyzos AA, et al. Mech Ageing Dev. 2017 Jan;161(Pt A):181-197. doi: 10.1016/j.mad.2016.09.003. Epub 2016 Sep 12. Mech Ageing Dev. 2017. PMID: 27634555 Free PMC article. Review.

4

Close encounters: Moving along bumps, breaks, and bubbles on expanded trinucleotide tracts.

Polyzos AA, McMurray CT. Polyzos AA, et al. DNA Repair (Amst). 2017 Aug;56:144-155. doi: 10.1016/j.dnarep.2017.06.017. Epub 2017 Jun 9. DNA Repair (Amst). 2017. PMID: 28690053 Free PMC article. Review.

5

Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice.

Polyzos AA, Lee DY, Datta R, Hauser M, Budworth H, Holt A, Mihalik S, Goldschmidt P, Frankel K, Trego K, Bennett MJ, Vockley J, Xu K, Gratton E, McMurray CT. Polyzos AA, et al. Cell Metab. 2019 Jun 4;29(6):1258-1273.e11. doi: 10.1016/j.cmet.2019.03.004. Epub 2019 Mar 28. Cell Metab. 2019. PMID: 30930170 Free PMC article.

6

An infrared spectral biomarker accurately predicts neurodegenerative disease class in the absence of overt symptoms.

Lovergne L, Ghosh D, Schuck R, Polyzos AA, Chen AD, Martin MC, Barnard ES, Brown JB, McMurray CT. Lovergne L, et al. Among authors: polyzos aa. Sci Rep. 2021 Aug 2;11(1):15598. doi: 10.1038/s41598-021-93686-8. Sci Rep. 2021. PMID: 34341363 Free PMC article.

7

A Double-Pronged Sword: XJB-5-131 Is a Suppressor of Somatic Instability and Toxicity in Huntington's Disease.

Wipf P, Polyzos AA, McMurray CT. Wipf P, et al. Among authors: polyzos aa. J Huntingtons Dis. 2022;11(1):3-15. doi: 10.3233/JHD-210510. J Huntingtons Dis. 2022. PMID: 34924397 Free PMC article. Review.

8

Flap Endonuclease 1 Endonucleolytically Processes RNA to Resolve R-Loops through DNA Base Excision Repair.

Laverde EE, Polyzos AA, Tsegay PP, Shaver M, Hutcheson JD, Balakrishnan L, McMurray CT, Liu Y. Laverde EE, et al. Among authors: polyzos aa. Genes (Basel). 2022 Dec 29;14(1):98. doi: 10.3390/genes14010098. Genes (Basel). 2022. PMID: 36672839 Free PMC article.

9

Base excision repair and double strand break repair cooperate to modulate the formation of unrepaired double strand breaks in mouse brain.

Polyzos AA, Cheong A, Yoo JH, Blagec L, Toprani SM, Nagel ZD, McMurray CT. Polyzos AA, et al. Nat Commun. 2024 Sep 4;15(1):7726. doi: 10.1038/s41467-024-51906-5. Nat Commun. 2024. PMID: 39231940 Free PMC article.

10

Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair.

Chiolo I, Minoda A, Colmenares SU, Polyzos A, Costes SV, Karpen GH. Chiolo I, et al. Cell. 2011 Mar 4;144(5):732-44. doi: 10.1016/j.cell.2011.02.012. Epub 2011 Feb 25. Cell. 2011. PMID: 21353298 Free PMC article.

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