de Garavilla L - Search Results

1

Extended cleavage specificity of human neutrophil cathepsin G: A low activity protease with dual chymase and tryptase-type specificities.

Thorpe M, Fu Z, Chahal G, Akula S, Kervinen J, de Garavilla L, Hellman L. Thorpe M, et al. Among authors: de garavilla l. PLoS One. 2018 Apr 13;13(4):e0195077. doi: 10.1371/journal.pone.0195077. eCollection 2018. PLoS One. 2018. PMID: 29652924 Free PMC article.

2

Highly Selective Cleavage of Cytokines and Chemokines by the Human Mast Cell Chymase and Neutrophil Cathepsin G.

Fu Z, Thorpe M, Alemayehu R, Roy A, Kervinen J, de Garavilla L, Åbrink M, Hellman L. Fu Z, et al. Among authors: de garavilla l. J Immunol. 2017 Feb 15;198(4):1474-1483. doi: 10.4049/jimmunol.1601223. Epub 2017 Jan 4. J Immunol. 2017. PMID: 28053237

3

Extended cleavage specificity of sheep mast cell protease-2: A classical chymase with preference to aromatic P1 substrate residues.

Fu Z, Akula S, Thorpe M, Chahal G, de Garavilla L, Kervinen J, Hellman L. Fu Z, et al. Among authors: de garavilla l. Dev Comp Immunol. 2019 Mar;92:160-169. doi: 10.1016/j.dci.2018.11.019. Epub 2018 Nov 24. Dev Comp Immunol. 2019. PMID: 30481523

4

Extended cleavage specificities of mast cell proteases 1 and 2 from golden hamster: Classical chymase and an elastolytic protease comparable to rat and mouse MCP-5.

Thorpe M, Fu Z, Albat E, Akula S, de Garavilla L, Kervinen J, Hellman L. Thorpe M, et al. Among authors: de garavilla l. PLoS One. 2018 Dec 6;13(12):e0207826. doi: 10.1371/journal.pone.0207826. eCollection 2018. PLoS One. 2018. PMID: 30521603 Free PMC article.

5

Extended Cleavage Specificities of Rabbit and Guinea Pig Mast Cell Chymases: Two Highly Specific Leu-Ases.

Zhongwei Y, Akula S, Fu Z, de Garavilla L, Kervinen J, Thorpe M, Hellman L. Zhongwei Y, et al. Among authors: de garavilla l. Int J Mol Sci. 2019 Dec 16;20(24):6340. doi: 10.3390/ijms20246340. Int J Mol Sci. 2019. PMID: 31888202 Free PMC article.

6

Duodenases are a small subfamily of ruminant intestinal serine proteases that have undergone a remarkable diversification in cleavage specificity.

Fu Z, Akula S, Qiao C, Ryu J, Chahal G, de Garavilla L, Kervinen J, Thorpe M, Hellman L. Fu Z, et al. Among authors: de garavilla l. PLoS One. 2021 May 28;16(5):e0252624. doi: 10.1371/journal.pone.0252624. eCollection 2021. PLoS One. 2021. PMID: 34048501 Free PMC article.

7

Potency variation of small-molecule chymase inhibitors across species.

Kervinen J, Crysler C, Bayoumy S, Abad MC, Spurlino J, Deckman I, Greco MN, Maryanoff BE, de Garavilla L. Kervinen J, et al. Among authors: de garavilla l. Biochem Pharmacol. 2010 Oct 1;80(7):1033-41. doi: 10.1016/j.bcp.2010.06.014. Epub 2010 Jun 23. Biochem Pharmacol. 2010. PMID: 20599788

8

Cleaved SLPI, a novel biomarker of chymase activity.

Belkowski SM, Masucci J, Mahan A, Kervinen J, Olson M, de Garavilla L, D'Andrea MR. Belkowski SM, et al. Among authors: de garavilla l. Biol Chem. 2008 Sep;389(9):1219-24. doi: 10.1515/BC.2008.138. Biol Chem. 2008. PMID: 18713008

9

Structural basis for elastolytic substrate specificity in rodent alpha-chymases.

Kervinen J, Abad M, Crysler C, Kolpak M, Mahan AD, Masucci JA, Bayoumy S, Cummings MD, Yao X, Olson M, de Garavilla L, Kuo L, Deckman I, Spurlino J. Kervinen J, et al. Among authors: de garavilla l. J Biol Chem. 2008 Jan 4;283(1):427-436. doi: 10.1074/jbc.M707157200. Epub 2007 Oct 31. J Biol Chem. 2008. PMID: 17981788 Free article.

10

A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.

de Garavilla L, Greco MN, Sukumar N, Chen ZW, Pineda AO, Mathews FS, Di Cera E, Giardino EC, Wells GI, Haertlein BJ, Kauffman JA, Corcoran TW, Derian CK, Eckardt AJ, Damiano BP, Andrade-Gordon P, Maryanoff BE. de Garavilla L, et al. J Biol Chem. 2005 May 6;280(18):18001-7. doi: 10.1074/jbc.M501302200. Epub 2005 Feb 28. J Biol Chem. 2005. PMID: 15741158 Free article.

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