El-Sharkawy LY - Search Results

1

Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors.

El-Sharkawy LY, El-Sakhawy RA, Abdel-Halim M, Lee K, Piazza GA, Ducho C, Hartmann RW, Abadi AH. El-Sharkawy LY, et al. Arch Pharm (Weinheim). 2018 May;351(5):e1800018. doi: 10.1002/ardp.201800018. Epub 2018 Apr 14. Arch Pharm (Weinheim). 2018. PMID: 29656464

2

Synthesis of novel 1,2-diarylpyrazolidin-3-one-based compounds and their evaluation as broad spectrum antibacterial agents.

Mokbel SA, Fathalla RK, El-Sharkawy LY, Abadi AH, Engel M, Abdel-Halim M. Mokbel SA, et al. Among authors: el sharkawy ly. Bioorg Chem. 2020 Jun;99:103759. doi: 10.1016/j.bioorg.2020.103759. Epub 2020 Mar 14. Bioorg Chem. 2020. PMID: 32220665

3

Inhibiting the NLRP3 Inflammasome.

El-Sharkawy LY, Brough D, Freeman S. El-Sharkawy LY, et al. Molecules. 2020 Nov 25;25(23):5533. doi: 10.3390/molecules25235533. Molecules. 2020. PMID: 33255820 Free PMC article. Review.

4

Selective inhibition of the K⁺ efflux sensitive NLRP3 pathway by Cl^- channel modulation.

Swanton T, Beswick JA, Hammadi H, Morris L, Williams D, de Cesco S, El-Sharkawy L, Yu S, Green J, Davis JB, Lawrence CB, Brough D, Freeman S. Swanton T, et al. Chem Sci. 2020 Oct 12;11(43):11720-11728. doi: 10.1039/d0sc03828h. Chem Sci. 2020. PMID: 34094411 Free PMC article.

5

LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation.

Green JP, Swanton T, Morris LV, El-Sharkawy LY, Cook J, Yu S, Beswick J, Adamson AD, Humphreys NE, Bryce R, Freeman S, Lawrence C, Brough D. Green JP, et al. Among authors: el sharkawy ly. Elife. 2020 Nov 20;9:e59704. doi: 10.7554/eLife.59704. Elife. 2020. PMID: 33216713 Free PMC article.

6

Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome.

Green JP, El-Sharkawy LY, Roth S, Zhu J, Cao J, Leach AG, Liesz A, Freeman S, Brough D. Green JP, et al. Among authors: el sharkawy ly. iScience. 2023 Apr 27;26(5):106758. doi: 10.1016/j.isci.2023.106758. eCollection 2023 May 19. iScience. 2023. PMID: 37216118 Free PMC article.

7

Computational Evaluation of Azadirachta indica-Derived Bioactive Compounds as Potential Inhibitors of NLRP3 in the Treatment of Alzheimer's Disease.

Ishabiyi FO, Ogidi JO, Olukade BA, Amorha CC, El-Sharkawy LY, Okolo CC, Adeniyi TM, Atasie NH, Ibrahim A, Balogun TA. Ishabiyi FO, et al. Among authors: el sharkawy ly. J Alzheimers Dis. 2023;94(s1):S67-S85. doi: 10.3233/JAD-221020. J Alzheimers Dis. 2023. PMID: 36683510 Free PMC article.

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