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Non-Clinical Efficacy and Safety Studies on G1XCGD, a Lentiviral Vector for Ex Vivo Gene Therapy of X-Linked Chronic Granulomatous Disease.
Brendel C, Rothe M, Santilli G, Charrier S, Stein S, Kunkel H, Abriss D, Müller-Kuller U, Gaspar B, Modlich U, Galy A, Schambach A, Thrasher AJ, Grez M. Brendel C, et al. Among authors: schambach a. Hum Gene Ther Clin Dev. 2018 Jun;29(2):69-79. doi: 10.1089/humc.2017.245. Epub 2018 Apr 17. Hum Gene Ther Clin Dev. 2018. PMID: 29664709
Self-inactivating retroviral vectors with improved RNA processing.
Kraunus J, Schaumann DH, Meyer J, Modlich U, Fehse B, Brandenburg G, von Laer D, Klump H, Schambach A, Bohne J, Baum C. Kraunus J, et al. Among authors: schambach a. Gene Ther. 2004 Nov;11(21):1568-78. doi: 10.1038/sj.gt.3302309. Gene Ther. 2004. PMID: 15372067
Gene therapy: X-SCID transgene leukaemogenicity.
Thrasher AJ, Gaspar HB, Baum C, Modlich U, Schambach A, Candotti F, Otsu M, Sorrentino B, Scobie L, Cameron E, Blyth K, Neil J, Abina SH, Cavazzana-Calvo M, Fischer A. Thrasher AJ, et al. Among authors: schambach a. Nature. 2006 Sep 21;443(7109):E5-6; discussion E6-7. doi: 10.1038/nature05219. Nature. 2006. PMID: 16988659
Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells.
Zhang F, Thornhill SI, Howe SJ, Ulaganathan M, Schambach A, Sinclair J, Kinnon C, Gaspar HB, Antoniou M, Thrasher AJ. Zhang F, et al. Among authors: schambach a. Blood. 2007 Sep 1;110(5):1448-57. doi: 10.1182/blood-2006-12-060814. Epub 2007 Apr 24. Blood. 2007. PMID: 17456723 Free PMC article.
369 results