Du H - Search Results

1

TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.

Liu HJ, Lizotte PH, Du H, Speranza MC, Lam HC, Vaughan S, Alesi N, Wong KK, Freeman GJ, Sharpe AH, Henske EP. Liu HJ, et al. Among authors: du h. JCI Insight. 2018 Apr 19;3(8):e98674. doi: 10.1172/jci.insight.98674. eCollection 2018 Apr 19. JCI Insight. 2018. PMID: 29669930 Free PMC article.

2

Analysis of a Mouse Skin Model of Tuberous Sclerosis Complex.

Guo Y, Dreier JR, Cao J, Du H, Granter SR, Kwiatkowski DJ. Guo Y, et al. Among authors: du h. PLoS One. 2016 Dec 1;11(12):e0167384. doi: 10.1371/journal.pone.0167384. eCollection 2016. PLoS One. 2016. PMID: 27907099 Free PMC article.

3

Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells.

Lam HC, Liu HJ, Baglini CV, Filippakis H, Alesi N, Nijmeh J, Du H, Lope AL, Cottrill KA, Handen A, Asara JM, Kwiatkowski DJ, Ben-Sahra I, Oldham WM, Chan SY, Henske EP. Lam HC, et al. Among authors: du h. Oncotarget. 2017 Aug 4;8(39):64714-64727. doi: 10.18632/oncotarget.19947. eCollection 2017 Sep 12. Oncotarget. 2017. PMID: 29029388 Free PMC article.

4

A novel mouse model of hemangiopericytoma due to loss of Tsc2.

Du H, Dreier JR, Zarei M, Wu CL, Bronson RW, Kwiatkowski DJ. Du H, et al. Hum Mol Genet. 2018 Dec 15;27(24):4169-4175. doi: 10.1093/hmg/ddy289. Hum Mol Genet. 2018. PMID: 30124871 Free PMC article.

5

Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion.

Zarei M, Du H, Nassar AH, Yan RE, Giannikou K, Johnson SH, Lam HC, Henske EP, Wang Y, Zhang T, Asara J, Kwiatkowski DJ. Zarei M, et al. Among authors: du h. J Exp Med. 2019 Nov 4;216(11):2635-2652. doi: 10.1084/jem.20190251. Epub 2019 Sep 10. J Exp Med. 2019. PMID: 31506280 Free PMC article.

6

MITF is a driver oncogene and potential therapeutic target in kidney angiomyolipoma tumors through transcriptional regulation of CYR61.

Zarei M, Giannikou K, Du H, Liu HJ, Duarte M, Johnson S, Nassar AH, Widlund HR, Henske EP, Long HW, Kwiatkowski DJ. Zarei M, et al. Among authors: du h. Oncogene. 2021 Jan;40(1):112-126. doi: 10.1038/s41388-020-01504-8. Epub 2020 Oct 20. Oncogene. 2021. PMID: 33082558 Free PMC article.

7

Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells.

Wang J, Filippakis H, Hougard T, Du H, Ye C, Liu HJ, Zhang L, Hindi K, Bagwe S, Nijmeh J, Asara JM, Shi W, El-Chemaly S, Henske EP, Lam HC. Wang J, et al. Among authors: du h. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2101268118. doi: 10.1073/pnas.2101268118. Proc Natl Acad Sci U S A. 2021. PMID: 34544857 Free PMC article.

8

Epigenomic charting and functional annotation of risk loci in renal cell carcinoma.

Nassar AH, Abou Alaiwi S, Baca SC, Adib E, Corona RI, Seo JH, Fonseca MAS, Spisak S, El Zarif T, Tisza V, Braun DA, Du H, He M, Flaifel A, Alchoueiry M, Denize T, Matar SG, Acosta A, Shukla S, Hou Y, Steinharter J, Bouchard G, Berchuck JE, O'Connor E, Bell C, Nuzzo PV, Mary Lee GS, Signoretti S, Hirsch MS, Pomerantz M, Henske E, Gusev A, Lawrenson K, Choueiri TK, Kwiatkowski DJ, Freedman ML. Nassar AH, et al. Among authors: du h. Nat Commun. 2023 Jan 21;14(1):346. doi: 10.1038/s41467-023-35833-5. Nat Commun. 2023. PMID: 36681680 Free PMC article.

9

mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion.

Liu HJ, Du H, Khabibullin D, Zarei M, Wei K, Freeman GJ, Kwiatkowski DJ, Henske EP. Liu HJ, et al. Among authors: du h. Nat Commun. 2023 Mar 3;14(1):1214. doi: 10.1038/s41467-023-36881-7. Nat Commun. 2023. PMID: 36869048 Free PMC article.

10

Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1.

Du H, Yang YC, Liu HJ, Yuan M, Asara JM, Wong KK, Henske EP, Singh M, Kwiatkowski DJ. Du H, et al. J Clin Invest. 2023 Nov 1;133(21):e167861. doi: 10.1172/JCI167861. J Clin Invest. 2023. PMID: 37909334 Free PMC article.

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