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ONO-8590580, a Novel GABAAα5 Negative Allosteric Modulator Enhances Long-Term Potentiation and Improves Cognitive Deficits in Preclinical Models.
Kawaharada S, Nakanishi M, Nakanishi N, Hazama K, Higashino M, Yasuhiro T, Lewis A, Clark GS, Chambers MS, Maidment SA, Katsumata S, Kaneko S. Kawaharada S, et al. Among authors: higashino m. J Pharmacol Exp Ther. 2018 Jul;366(1):58-65. doi: 10.1124/jpet.117.247627. Epub 2018 Apr 19. J Pharmacol Exp Ther. 2018. PMID: 29674331
Discovery of ONO-8590580: A novel, potent and selective GABAA α5 negative allosteric modulator for the treatment of cognitive disorders.
Lewis A, Beresford A, Chambers MS, Clark G, Hartley DC, Hirst KL, Higashino M, Kawahadara S, Nakanishi M, Saito T, Imagawa A, Habashita H, Maidment S, Macleod AM, Owens AP, Rae A, Rouse C, Wishart G. Lewis A, et al. Among authors: higashino m. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127536. doi: 10.1016/j.bmcl.2020.127536. Epub 2020 Sep 6. Bioorg Med Chem Lett. 2020. PMID: 32898695
Synthesis and evaluation of a potent, well-balanced EP2/EP3 dual agonist.
Kinoshita A, Higashino M, Yoshida K, Aratani Y, Kakuuchi A, Hanada K, Takeda H, Naganawa A, Matsuya H, Ohmoto K. Kinoshita A, et al. Among authors: higashino m. Bioorg Med Chem. 2018 Jan 1;26(1):200-214. doi: 10.1016/j.bmc.2017.11.035. Epub 2017 Nov 24. Bioorg Med Chem. 2018. PMID: 29203142
Publisher Correction: Clinical factors to predict changes of esophagogastric varices after sustained viral response with direct-acting antiviral therapy.
Watanabe T, Tokumoto Y, Ochi H, Mashiba T, Tada F, Hiraoka A, Kisaka Y, Tanaka Y, Yagi S, Nakanishi S, Sunago K, Yamauchi K, Higashino M, Hirooka K, Tange M, Yukimoto A, Morita M, Okazaki Y, Hirooka M, Abe M, Hiasa Y. Watanabe T, et al. Among authors: higashino m. J Gastroenterol. 2025 Jan 12. doi: 10.1007/s00535-024-02196-7. Online ahead of print. J Gastroenterol. 2025. PMID: 39799525 No abstract available.
Linked color imaging and upper gastrointestinal neoplasia.
Ono S, Inoue M, Higashino M, Hayasaka S, Tanaka S, Egami H, Sakamoto N. Ono S, et al. Among authors: higashino m. Dig Endosc. 2024 Nov 25. doi: 10.1111/den.14957. Online ahead of print. Dig Endosc. 2024. PMID: 39582388 Review.
Clinical factors to predict changes of esophagogastric varices after sustained viral response with direct-acting antiviral therapy.
Watanabe T, Tokumoto Y, Ochi H, Mashiba T, Tada F, Hiraoka A, Kisaka Y, Tanaka Y, Yagi S, Nakanishi S, Sunago K, Yamauchi K, Higashino M, Hirooka K, Tange M, Yukimoto A, Morita M, Okazaki Y, Hirooka M, Abe M, Hiasa Y. Watanabe T, et al. Among authors: higashino m. J Gastroenterol. 2024 Nov 15. doi: 10.1007/s00535-024-02174-z. Online ahead of print. J Gastroenterol. 2024. PMID: 39545995
225 results