Durk MR - Search Results

1

Use of Subcutaneous and Intraperitoneal Administration Methods to Facilitate Cassette Dosing in Microdialysis Studies in Rats.

Durk MR, Deshmukh G, Valle N, Ding X, Liederer BM, Liu X. Durk MR, et al. Drug Metab Dispos. 2018 Jul;46(7):964-969. doi: 10.1124/dmd.118.080697. Epub 2018 Apr 26. Drug Metab Dispos. 2018. PMID: 29700231

2

Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat.

Fan PW, Chen JZ, Allan Jaochico M, La H, Liu N, Mulder T, Cass RT, Durk M, Messick K, Valle N, Liu S, Lee W, Crawford JJ, Rudolf J, Murray LJ, Cyrus Khojasteh S, Wright M. Fan PW, et al. Drug Metab Lett. 2016;10(2):91-100. doi: 10.2174/1872312810666160411144358. Drug Metab Lett. 2016. PMID: 27063863 Free PMC article.

3

Quantitative Intracerebral Microdialysis Studies to Determine Unbound Extracellular Fluid Drug Concentrations in Discrete Areas of the Brain.

Durk MR. Durk MR. Curr Protoc Pharmacol. 2018 Mar;80(1):7.18.1-7.18.19. doi: 10.1002/cpph.38. Curr Protoc Pharmacol. 2018. PMID: 30040217

4

Evaluating the Pharmacokinetics and Systemic Effects of a Permeability Enhancer Sodium N-[8-(2-hydroxybenzoyl)amino] Caprylate in Rats.

Chiang PC, Deshmukh G, Liu J, Nagapudi K, Chen JZ, Valle N, Li R, Plise EG, Durk MR. Chiang PC, et al. Among authors: durk mr. J Pharm Sci. 2020 Aug;109(8):2629-2636. doi: 10.1016/j.xphs.2020.04.016. Epub 2020 Apr 28. J Pharm Sci. 2020. PMID: 32360544

5

Vitamin D receptor activation induces P-glycoprotein and increases brain efflux of quinidine: an intracerebral microdialysis study in conscious rats.

Durk MR, Fan J, Sun H, Yang Y, Pang H, Pang KS, de Lannoy IA. Durk MR, et al. Pharm Res. 2015 Mar;32(3):1128-40. doi: 10.1007/s11095-014-1524-y. Epub 2014 Oct 16. Pharm Res. 2015. PMID: 25319098

6

Design and Measurement of Drug Tissue Concentration Asymmetry and Tissue Exposure-Effect (Tissue PK-PD) Evaluation.

Zang R, Barth A, Wong H, Marik J, Shen J, Lade J, Grove K, Durk MR, Parrott N, Rudewicz PJ, Zhao S, Wang T, Yan Z, Zhang D. Zang R, et al. Among authors: durk mr. J Med Chem. 2022 Jul 14;65(13):8713-8734. doi: 10.1021/acs.jmedchem.2c00502. Epub 2022 Jul 5. J Med Chem. 2022. PMID: 35790118 Review.

7

Phase I and scintigraphy studies to evaluate safety, tolerability, pharmacokinetics, and lung deposition of inhaled GDC-0214 in healthy volunteers.

Zhu R, Chen H, Galanter J, She G, Cai F, Durk MR, Zou Y, Chen L, Kenny JR, Vadhavkar S, Warren S, Taylor G, Hwang O, Eliahu A, Wynne C, Owen R. Zhu R, et al. Among authors: durk mr. Clin Transl Sci. 2022 May;15(5):1225-1237. doi: 10.1111/cts.13240. Epub 2022 Feb 26. Clin Transl Sci. 2022. PMID: 35157370 Free PMC article. Clinical Trial.

8

Complex DDI by Fenebrutinib and the Use of Transporter Endogenous Biomarkers to Elucidate the Mechanism of DDI.

Jones NS, Yoshida K, Salphati L, Kenny JR, Durk MR, Chinn LW. Jones NS, et al. Among authors: durk mr. Clin Pharmacol Ther. 2020 Jan;107(1):269-277. doi: 10.1002/cpt.1599. Epub 2019 Sep 16. Clin Pharmacol Ther. 2020. PMID: 31376152 Free PMC article. Clinical Trial.

9

Physiologically-Based Pharmacokinetic Model-Informed Drug Development for Fenebrutinib: Understanding Complex Drug-Drug Interactions.

Chen Y, Ma F, Jones NS, Yoshida K, Chiang PC, Durk MR, Wright MR, Jin JY, Chinn LW. Chen Y, et al. Among authors: durk mr. CPT Pharmacometrics Syst Pharmacol. 2020 Jun;9(6):332-341. doi: 10.1002/psp4.12515. Epub 2020 May 29. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32383787 Free PMC article.

10

Optimized arylomycins are a new class of Gram-negative antibiotics.

Smith PA, Koehler MFT, Girgis HS, Yan D, Chen Y, Chen Y, Crawford JJ, Durk MR, Higuchi RI, Kang J, Murray J, Paraselli P, Park S, Phung W, Quinn JG, Roberts TC, Rougé L, Schwarz JB, Skippington E, Wai J, Xu M, Yu Z, Zhang H, Tan MW, Heise CE. Smith PA, et al. Among authors: durk mr. Nature. 2018 Sep;561(7722):189-194. doi: 10.1038/s41586-018-0483-6. Epub 2018 Sep 12. Nature. 2018. PMID: 30209367

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