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Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation.
Pekkonen P, Alve S, Balistreri G, Gramolelli S, Tatti-Bugaeva O, Paatero I, Niiranen O, Tuohinto K, Perälä N, Taiwo A, Zinovkina N, Repo P, Icay K, Ivaska J, Saharinen P, Hautaniemi S, Lehti K, Ojala PM. Pekkonen P, et al. Among authors: hautaniemi s. Elife. 2018 May 1;7:e32490. doi: 10.7554/eLife.32490. Elife. 2018. PMID: 29712618 Free PMC article.
KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition.
Cheng F, Pekkonen P, Laurinavicius S, Sugiyama N, Henderson S, Günther T, Rantanen V, Kaivanto E, Aavikko M, Sarek G, Hautaniemi S, Biberfeld P, Aaltonen L, Grundhoff A, Boshoff C, Alitalo K, Lehti K, Ojala PM. Cheng F, et al. Among authors: hautaniemi s. Cell Host Microbe. 2011 Dec 15;10(6):577-90. doi: 10.1016/j.chom.2011.10.011. Cell Host Microbe. 2011. PMID: 22177562 Free article.
MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma.
Tatti O, Gucciardo E, Pekkonen P, Holopainen T, Louhimo R, Repo P, Maliniemi P, Lohi J, Rantanen V, Hautaniemi S, Alitalo K, Ranki A, Ojala PM, Keski-Oja J, Lehti K. Tatti O, et al. Among authors: hautaniemi s. Cancer Res. 2015 May 15;75(10):2083-94. doi: 10.1158/0008-5472.CAN-14-1923. Epub 2015 Mar 25. Cancer Res. 2015. PMID: 25808867
Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication.
Balistreri G, Viiliäinen J, Turunen M, Diaz R, Lyly L, Pekkonen P, Rantala J, Ojala K, Sarek G, Teesalu M, Denisova O, Peltonen K, Julkunen I, Varjosalo M, Kainov D, Kallioniemi O, Laiho M, Taipale J, Hautaniemi S, Ojala PM. Balistreri G, et al. Among authors: hautaniemi s. PLoS Pathog. 2016 Feb 18;12(2):e1005424. doi: 10.1371/journal.ppat.1005424. eCollection 2016 Feb. PLoS Pathog. 2016. PMID: 26891221 Free PMC article.
MicroRNAs regulate key cell survival pathways and mediate chemosensitivity during progression of diffuse large B-cell lymphoma.
Leivonen SK, Icay K, Jäntti K, Siren I, Liu C, Alkodsi A, Cervera A, Ludvigsen M, Hamilton-Dutoit SJ, d'Amore F, Karjalainen-Lindsberg ML, Delabie J, Holte H, Lehtonen R, Hautaniemi S, Leppä S. Leivonen SK, et al. Among authors: hautaniemi s. Blood Cancer J. 2017 Dec 15;7(12):654. doi: 10.1038/s41408-017-0033-8. Blood Cancer J. 2017. PMID: 29242506 Free PMC article.
PROX1 is a transcriptional regulator of MMP14.
Gramolelli S, Cheng J, Martinez-Corral I, Vähä-Koskela M, Elbasani E, Kaivanto E, Rantanen V, Tuohinto K, Hautaniemi S, Bower M, Haglund C, Alitalo K, Mäkinen T, Petrova TV, Lehti K, Ojala PM. Gramolelli S, et al. Among authors: hautaniemi s. Sci Rep. 2018 Jun 22;8(1):9531. doi: 10.1038/s41598-018-27739-w. Sci Rep. 2018. PMID: 29934628 Free PMC article.
188 results