den Braver MW - Search Results

1

Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells.

Zhang Y, den Braver-Sewradj SP, den Braver MW, Hiemstra S, Vermeulen NPE, van de Water B, Commandeur JNM, Vos JC. Zhang Y, et al. Among authors: den braver mw. Front Pharmacol. 2018 Apr 18;9:388. doi: 10.3389/fphar.2018.00388. eCollection 2018. Front Pharmacol. 2018. PMID: 29720942 Free PMC article.

2

Cytochrome P450-mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases.

Venkataraman H, den Braver MW, Vermeulen NP, Commandeur JN. Venkataraman H, et al. Among authors: den braver mw. Chem Res Toxicol. 2014 Dec 15;27(12):2071-81. doi: 10.1021/tx500288b. Epub 2014 Nov 18. Chem Res Toxicol. 2014. PMID: 25372302

3

Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines.

den Braver MW, den Braver-Sewradj SP, Vermeulen NP, Commandeur JN. den Braver MW, et al. Toxicol Lett. 2016 Jun 24;253:46-54. doi: 10.1016/j.toxlet.2016.04.022. Epub 2016 Apr 26. Toxicol Lett. 2016. PMID: 27130197

4

Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol.

den Braver MW, Zhang Y, Venkataraman H, Vermeulen NP, Commandeur JN. den Braver MW, et al. Toxicol Lett. 2016 Jul 25;255:52-62. doi: 10.1016/j.toxlet.2016.05.015. Epub 2016 May 13. Toxicol Lett. 2016. PMID: 27183920

5

Generic method for the absolute quantification of glutathione S-conjugates: Application to the conjugates of acetaminophen, clozapine and diclofenac.

den Braver MW, Vermeulen NPE, Commandeur JNM. den Braver MW, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Mar 1;1046:185-194. doi: 10.1016/j.jchromb.2017.02.004. Epub 2017 Feb 6. J Chromatogr B Analyt Technol Biomed Life Sci. 2017. PMID: 28189104

6

Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations.

den Braver-Sewradj SP, den Braver MW, Toorneman RM, van Leeuwen S, Zhang Y, Dekker SJ, Vermeulen NPE, Commandeur JNM, Vos JC. den Braver-Sewradj SP, et al. Among authors: den braver mw. Chem Res Toxicol. 2018 Feb 19;31(2):116-126. doi: 10.1021/acs.chemrestox.7b00289. Epub 2018 Jan 11. Chem Res Toxicol. 2018. PMID: 29281794 Free PMC article.

7

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies.

Ramaiahgari SC, den Braver MW, Herpers B, Terpstra V, Commandeur JN, van de Water B, Price LS. Ramaiahgari SC, et al. Among authors: den braver mw. Arch Toxicol. 2014 May;88(5):1083-95. doi: 10.1007/s00204-014-1215-9. Epub 2014 Mar 6. Arch Toxicol. 2014. PMID: 24599296

8

Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer.

den Braver-Sewradj SP, den Braver MW, Vermeulen NP, Commandeur JN, Richert L, Vos JC. den Braver-Sewradj SP, et al. Among authors: den braver mw. Toxicol In Vitro. 2016 Jun;33:71-9. doi: 10.1016/j.tiv.2016.02.013. Epub 2016 Feb 26. Toxicol In Vitro. 2016. PMID: 26921663

9

Direct comparison of UDP-glucuronosyltransferase and cytochrome P450 activities in human liver microsomes, plated and suspended primary human hepatocytes from five liver donors.

den Braver-Sewradj SP, den Braver MW, Baze A, Decorde J, Fonsi M, Bachellier P, Vermeulen NPE, Commandeur JNM, Richert L, Vos JC. den Braver-Sewradj SP, et al. Among authors: den braver mw. Eur J Pharm Sci. 2017 Nov 15;109:96-110. doi: 10.1016/j.ejps.2017.07.032. Epub 2017 Aug 1. Eur J Pharm Sci. 2017. PMID: 28778465

10

Inter-individual Variability in Activity of the Major Drug Metabolizing Enzymes in Liver Homogenates of 20 Individuals.

den Braver-Sewradj SP, den Braver MW, van Dijk M, Zhang Y, Dekker SJ, Wijaya L, Vermeulen NPE, Richert L, Commandeur JNM, Vos JC. den Braver-Sewradj SP, et al. Among authors: den braver mw. Curr Drug Metab. 2018;19(4):370-381. doi: 10.2174/1389200219666180108160046. Curr Drug Metab. 2018. PMID: 29318967

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