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PCSK9 inhibition with alirocumab reduces lipoprotein(a) levels in nonhuman primates by lowering apolipoprotein(a) production rate.
Croyal M, Tran TT, Blanchard RH, Le Bail JC, Villard EF, Poirier B, Aguesse A, Billon-Crossouard S, Ramin-Mangata S, Blanchard V, Nativel B, Chemello K, Khantalin I, Thedrez A, Janiak P, Krempf M, Boixel C, Lambert G, Guillot E. Croyal M, et al. Among authors: poirier b. Clin Sci (Lond). 2018 May 31;132(10):1075-1083. doi: 10.1042/CS20180040. Print 2018 May 31. Clin Sci (Lond). 2018. PMID: 29724769
The complexity of lipoprotein (a) lowering by PCSK9 monoclonal antibodies.
Lambert G, Thedrez A, Croyal M, Ramin-Mangata S, Couret D, Diotel N, Nobécourt-Dupuy E, Krempf M, LeBail JC, Poirier B, Blankenstein J, Villard EF, Guillot E. Lambert G, et al. Among authors: poirier b. Clin Sci (Lond). 2017 Feb 1;131(4):261-268. doi: 10.1042/CS20160403. Clin Sci (Lond). 2017. PMID: 28108631 Review.
PCSK9 Modulates the Secretion But Not the Cellular Uptake of Lipoprotein(a) Ex Vivo: An Effect Blunted by Alirocumab.
Villard EF, Thedrez A, Blankenstein J, Croyal M, Tran TT, Poirier B, Le Bail JC, Illiano S, Nobécourt E, Krempf M, Blom DJ, Marais AD, Janiak P, Muslin AJ, Guillot E, Lambert G. Villard EF, et al. Among authors: poirier b. JACC Basic Transl Sci. 2016 Oct;1(6):419-427. doi: 10.1016/j.jacbts.2016.06.006. JACC Basic Transl Sci. 2016. PMID: 29308438 Free PMC article.
Lipoprotein(a) Cellular Uptake Ex Vivo and Hepatic Capture In Vivo Is Insensitive to PCSK9 Inhibition With Alirocumab.
Chemello K, Beeské S, Trang Tran TT, Blanchard V, Villard EF, Poirier B, Le Bail JC, Dargazanli G, Ho-Van-Guimbal S, Boulay D, Bergis O, Pruniaux MP, Croyal M, Janiak P, Guillot E, Lambert G. Chemello K, et al. Among authors: poirier b. JACC Basic Transl Sci. 2020 May 6;5(6):549-557. doi: 10.1016/j.jacbts.2020.03.008. eCollection 2020 Jun. JACC Basic Transl Sci. 2020. PMID: 32613143 Free PMC article.
High Glucose Activates YAP Signaling to Promote Vascular Inflammation.
Ortillon J, Le Bail JC, Villard E, Léger B, Poirier B, Girardot C, Beeske S, Ledein L, Blanchard V, Brieu P, Naimi S, Janiak P, Guillot E, Meloni M. Ortillon J, et al. Among authors: poirier b. Front Physiol. 2021 Jun 4;12:665994. doi: 10.3389/fphys.2021.665994. eCollection 2021. Front Physiol. 2021. PMID: 34149446 Free PMC article.
Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models.
Illiano S, Poirier B, Minoletti C, Pasquier O, Riva L, Chenede X, Menguy I, Guillotel M, Prigent P, Le Claire S, Gillot F, Thill G, Lo Presti F, Corbier A, Le Bail JC, Grailhe P, Monteagudo E, Ingenito R, Bianchi E, Philippo C, Duclos O, Mallart S, Bathgate R, Janiak P. Illiano S, et al. Among authors: poirier b. Sci Rep. 2022 Nov 28;12(1):20435. doi: 10.1038/s41598-022-24716-2. Sci Rep. 2022. PMID: 36443381 Free PMC article.
236 results