Grim JE - Search Results

1

Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism.

Davis RJ, Gönen M, Margineantu DH, Handeli S, Swanger J, Hoellerbauer P, Paddison PJ, Gu H, Raftery D, Grim JE, Hockenbery DM, Margolin AA, Clurman BE. Davis RJ, et al. Among authors: grim je. Proc Natl Acad Sci U S A. 2018 May 22;115(21):5462-5467. doi: 10.1073/pnas.1718338115. Epub 2018 May 7. Proc Natl Acad Sci U S A. 2018. PMID: 29735700 Free PMC article.

2

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation.

Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, Clurman BE. Welcker M, et al. Among authors: grim je. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9085-90. doi: 10.1073/pnas.0402770101. Epub 2004 May 18. Proc Natl Acad Sci U S A. 2004. PMID: 15150404 Free PMC article.

3

A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size.

Welcker M, Orian A, Grim JE, Eisenman RN, Clurman BE. Welcker M, et al. Among authors: grim je. Curr Biol. 2004 Oct 26;14(20):1852-7. doi: 10.1016/j.cub.2004.09.083. Curr Biol. 2004. PMID: 15498494 Free article.

4

Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase.

Grim JE, Gustafson MP, Hirata RK, Hagar AC, Swanger J, Welcker M, Hwang HC, Ericsson J, Russell DW, Clurman BE. Grim JE, et al. J Cell Biol. 2008 Jun 16;181(6):913-20. doi: 10.1083/jcb.200802076. J Cell Biol. 2008. PMID: 18559665 Free PMC article.

5

Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer.

Grim JE, Knoblaugh SE, Guthrie KA, Hagar A, Swanger J, Hespelt J, Delrow JJ, Small T, Grady WM, Nakayama KI, Clurman BE. Grim JE, et al. Mol Cell Biol. 2012 Jun;32(11):2160-7. doi: 10.1128/MCB.00305-12. Epub 2012 Apr 2. Mol Cell Biol. 2012. PMID: 22473991 Free PMC article.

6

Cycling without CDK2?

Grim JE, Clurman BE. Grim JE, et al. Trends Cell Biol. 2003 Aug;13(8):396-9. doi: 10.1016/s0962-8924(03)00148-x. Trends Cell Biol. 2003. PMID: 12888290

7

Fbw7 dimerization determines the specificity and robustness of substrate degradation.

Welcker M, Larimore EA, Swanger J, Bengoechea-Alonso MT, Grim JE, Ericsson J, Zheng N, Clurman BE. Welcker M, et al. Among authors: grim je. Genes Dev. 2013 Dec 1;27(23):2531-6. doi: 10.1101/gad.229195.113. Genes Dev. 2013. PMID: 24298052 Free PMC article.

8

Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation.

Welcker M, Singer J, Loeb KR, Grim J, Bloecher A, Gurien-West M, Clurman BE, Roberts JM. Welcker M, et al. Mol Cell. 2003 Aug;12(2):381-92. doi: 10.1016/s1097-2765(03)00287-9. Mol Cell. 2003. PMID: 14536078 Free article.

9

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors.

O'Neil J, Grim J, Strack P, Rao S, Tibbitts D, Winter C, Hardwick J, Welcker M, Meijerink JP, Pieters R, Draetta G, Sears R, Clurman BE, Look AT. O'Neil J, et al. J Exp Med. 2007 Aug 6;204(8):1813-24. doi: 10.1084/jem.20070876. Epub 2007 Jul 23. J Exp Med. 2007. PMID: 17646409 Free PMC article.

10

Regulation of cell proliferation in a stratified culture system of epithelial cells from prostate tissue.

Gustafson MP, Xu C, Grim JE, Clurman BE, Knudsen BS. Gustafson MP, et al. Among authors: grim je. Cell Tissue Res. 2006 Aug;325(2):263-76. doi: 10.1007/s00441-005-0093-0. Epub 2006 Mar 24. Cell Tissue Res. 2006. PMID: 16557385

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