McAlary L - Search Results

1

SOD1^A4V aggregation alters ubiquitin homeostasis in a cell model of ALS.

Farrawell NE, Lambert-Smith I, Mitchell K, McKenna J, McAlary L, Ciryam P, Vine KL, Saunders DN, Yerbury JJ. Farrawell NE, et al. Among authors: mcalary l. J Cell Sci. 2018 Jun 12;131(11):jcs209122. doi: 10.1242/jcs.209122. J Cell Sci. 2018. PMID: 29748379 Free PMC article.

2

Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis.

McAlary L, Yerbury JJ, Aquilina JA. McAlary L, et al. Sci Rep. 2013 Nov 20;3:3275. doi: 10.1038/srep03275. Sci Rep. 2013. PMID: 24253732 Free PMC article.

3

Rapid flow cytometric measurement of protein inclusions and nuclear trafficking.

Whiten DR, San Gil R, McAlary L, Yerbury JJ, Ecroyd H, Wilson MR. Whiten DR, et al. Among authors: mcalary l. Sci Rep. 2016 Aug 12;6:31138. doi: 10.1038/srep31138. Sci Rep. 2016. PMID: 27516358 Free PMC article.

4

Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity.

McAlary L, Aquilina JA, Yerbury JJ. McAlary L, et al. Front Neurosci. 2016 Nov 4;10:499. doi: 10.3389/fnins.2016.00499. eCollection 2016. Front Neurosci. 2016. PMID: 27867347 Free PMC article.

5

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation.

Zeineddine R, Whiten DR, Farrawell NE, McAlary L, Hanspal MA, Kumita JR, Wilson MR, Yerbury JJ. Zeineddine R, et al. Among authors: mcalary l. Prion. 2017 May 4;11(3):195-204. doi: 10.1080/19336896.2017.1314426. Epub 2017 May 9. Prion. 2017. PMID: 28486039 Free PMC article.

6

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.

Capper MJ, Wright GSA, Barbieri L, Luchinat E, Mercatelli E, McAlary L, Yerbury JJ, O'Neill PM, Antonyuk SV, Banci L, Hasnain SS. Capper MJ, et al. Among authors: mcalary l. Nat Commun. 2018 Apr 27;9(1):1693. doi: 10.1038/s41467-018-04114-x. Nat Commun. 2018. PMID: 29703933 Free PMC article.

7

Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells.

Pokrishevsky E, McAlary L, Farrawell NE, Zhao B, Sher M, Yerbury JJ, Cashman NR. Pokrishevsky E, et al. Among authors: mcalary l. Sci Rep. 2018 Oct 22;8(1):15590. doi: 10.1038/s41598-018-32835-y. Sci Rep. 2018. PMID: 30349065 Free PMC article.

8

CuATSM Protects Against the In Vitro Cytotoxicity of Wild-Type-Like Copper-Zinc Superoxide Dismutase Mutants but not Mutants That Disrupt Metal Binding.

Farrawell NE, Yerbury MR, Plotkin SS, McAlary L, Yerbury JJ. Farrawell NE, et al. Among authors: mcalary l. ACS Chem Neurosci. 2019 Mar 20;10(3):1555-1564. doi: 10.1021/acschemneuro.8b00527. Epub 2018 Dec 7. ACS Chem Neurosci. 2019. PMID: 30462490

9

CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)^G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1.

Silverman JM, Christy D, Shyu CC, Moon KM, Fernando S, Gidden Z, Cowan CM, Ban Y, Stacey RG, Grad LI, McAlary L, Mackenzie IR, Foster LJ, Cashman NR. Silverman JM, et al. Among authors: mcalary l. J Biol Chem. 2019 Mar 8;294(10):3744-3759. doi: 10.1074/jbc.RA118.004825. Epub 2019 Jan 11. J Biol Chem. 2019. PMID: 30635404 Free PMC article.

10

Strategies to promote the maturation of ALS-associated SOD1 mutants: small molecules return to the fold.

McAlary L, Yerbury JJ. McAlary L, et al. Neural Regen Res. 2019 Sep;14(9):1511-1512. doi: 10.4103/1673-5374.255962. Neural Regen Res. 2019. PMID: 31089043 Free PMC article. No abstract available.

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