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Prion protein monoclonal antibody (PRN100) therapy for Creutzfeldt-Jakob disease: evaluation of a first-in-human treatment programme.
Mead S, Khalili-Shirazi A, Potter C, Mok T, Nihat A, Hyare H, Canning S, Schmidt C, Campbell T, Darwent L, Muirhead N, Ebsworth N, Hextall P, Wakeling M, Linehan J, Libri V, Williams B, Jaunmuktane Z, Brandner S, Rudge P, Collinge J. Mead S, et al. Among authors: khalili shirazi a. Lancet Neurol. 2022 Apr;21(4):342-354. doi: 10.1016/S1474-4422(22)00082-5. Lancet Neurol. 2022. PMID: 35305340
Elongated oligomers assemble into mammalian PrP amyloid fibrils.
Tattum MH, Cohen-Krausz S, Thumanu K, Wharton CW, Khalili-Shirazi A, Jackson GS, Orlova EV, Collinge J, Clarke AR, Saibil HR. Tattum MH, et al. Among authors: khalili shirazi a. J Mol Biol. 2006 Mar 31;357(3):975-85. doi: 10.1016/j.jmb.2006.01.052. Epub 2006 Jan 31. J Mol Biol. 2006. PMID: 16473369
23 results