Holmes BB - Search Results

1

Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates.

Stopschinski BE, Holmes BB, Miller GM, Manon VA, Vaquer-Alicea J, Prueitt WL, Hsieh-Wilson LC, Diamond MI. Stopschinski BE, et al. Among authors: holmes bb. J Biol Chem. 2018 Jul 6;293(27):10826-10840. doi: 10.1074/jbc.RA117.000378. Epub 2018 May 11. J Biol Chem. 2018. PMID: 29752409 Free PMC article.

2

Trans-cellular propagation of Tau aggregation by fibrillar species.

Kfoury N, Holmes BB, Jiang H, Holtzman DM, Diamond MI. Kfoury N, et al. Among authors: holmes bb. J Biol Chem. 2012 Jun 1;287(23):19440-51. doi: 10.1074/jbc.M112.346072. Epub 2012 Mar 29. J Biol Chem. 2012. PMID: 22461630 Free PMC article.

3

Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target.

Holmes BB, Diamond MI. Holmes BB, et al. J Biol Chem. 2014 Jul 18;289(29):19855-61. doi: 10.1074/jbc.R114.549295. Epub 2014 May 23. J Biol Chem. 2014. PMID: 24860099 Free PMC article. Review.

4

Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation.

Mirbaha H, Holmes BB, Sanders DW, Bieschke J, Diamond MI. Mirbaha H, et al. Among authors: holmes bb. J Biol Chem. 2015 Jun 12;290(24):14893-903. doi: 10.1074/jbc.M115.652693. Epub 2015 Apr 17. J Biol Chem. 2015. PMID: 25887395 Free PMC article.

5

Cellular Models for the Study of Prions.

Holmes BB, Diamond MI. Holmes BB, et al. Cold Spring Harb Perspect Med. 2017 Feb 1;7(2):a024026. doi: 10.1101/cshperspect.a024026. Cold Spring Harb Perspect Med. 2017. PMID: 27815306 Free PMC article. Review.

6

Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics.

Yamasaki TR, Holmes BB, Furman JL, Dhavale DD, Su BW, Song ES, Cairns NJ, Kotzbauer PT, Diamond MI. Yamasaki TR, et al. Among authors: holmes bb. J Biol Chem. 2019 Jan 18;294(3):1045-1058. doi: 10.1074/jbc.RA118.004471. Epub 2018 Nov 26. J Biol Chem. 2019. PMID: 30478174 Free PMC article.

7

A synthetic heparinoid blocks Tau aggregate cell uptake and amplification.

Stopschinski BE, Thomas TL, Nadji S, Darvish E, Fan L, Holmes BB, Modi AR, Finnell JG, Kashmer OM, Estill-Terpack S, Mirbaha H, Luu HS, Diamond MI. Stopschinski BE, et al. Among authors: holmes bb. J Biol Chem. 2020 Mar 6;295(10):2974-2983. doi: 10.1074/jbc.RA119.010353. Epub 2020 Jan 23. J Biol Chem. 2020. PMID: 31974166 Free PMC article.

8

Cellular mechanisms of protein aggregate propagation.

Holmes BB, Diamond MI. Holmes BB, et al. Curr Opin Neurol. 2012 Dec;25(6):721-6. doi: 10.1097/WCO.0b013e32835a3ee0. Curr Opin Neurol. 2012. PMID: 23108252 Free PMC article. Review.

9

An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1.

Zheng Z, Li A, Holmes BB, Marasa JC, Diamond MI. Zheng Z, et al. Among authors: holmes bb. J Biol Chem. 2013 Mar 1;288(9):6063-71. doi: 10.1074/jbc.M112.413575. Epub 2013 Jan 14. J Biol Chem. 2013. PMID: 23319588 Free PMC article.

10

Sensitive Detection of Proteopathic Seeding Activity with FRET Flow Cytometry.

Furman JL, Holmes BB, Diamond MI. Furman JL, et al. Among authors: holmes bb. J Vis Exp. 2015 Dec 8;(106):e53205. doi: 10.3791/53205. J Vis Exp. 2015. PMID: 26710240 Free PMC article.

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