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Page 1
BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.
Jennings LE, Schiedel M, Hewings DS, Picaud S, Laurin CMC, Bruno PA, Bluck JP, Scorah AR, See L, Reynolds JK, Moroglu M, Mistry IN, Hicks A, Guzanov P, Clayton J, Evans CNG, Stazi G, Biggin PC, Mapp AK, Hammond EM, Humphreys PG, Filippakopoulos P, Conway SJ. Jennings LE, et al. Among authors: mistry in. Bioorg Med Chem. 2018 Jul 15;26(11):2937-2957. doi: 10.1016/j.bmc.2018.05.003. Epub 2018 May 15. Bioorg Med Chem. 2018. PMID: 29776834 Free article.
Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor.
Skwarska A, Calder EDD, Sneddon D, Bolland H, Odyniec ML, Mistry IN, Martin J, Folkes LK, Conway SJ, Hammond EM. Skwarska A, et al. Among authors: mistry in. Cell Chem Biol. 2021 Sep 16;28(9):1258-1270.e13. doi: 10.1016/j.chembiol.2021.04.004. Epub 2021 Apr 27. Cell Chem Biol. 2021. PMID: 33910023 Free PMC article.
Hypoxia drives the assembly of the multienzyme purinosome complex.
Doigneaux C, Pedley AM, Mistry IN, Papayova M, Benkovic SJ, Tavassoli A. Doigneaux C, et al. Among authors: mistry in. J Biol Chem. 2020 Jul 10;295(28):9551-9566. doi: 10.1074/jbc.RA119.012175. Epub 2020 May 21. J Biol Chem. 2020. PMID: 32439803 Free PMC article.