Gong J - Search Results

1

Further Studies to Support the Use of Coproporphyrin I and III as Novel Clinical Biomarkers for Evaluating the Potential for Organic Anion Transporting Polypeptide 1B1 and OATP1B3 Inhibition.

Shen H, Christopher L, Lai Y, Gong J, Kandoussi H, Garonzik S, Perera V, Garimella T, Humphreys WG. Shen H, et al. Among authors: gong j. Drug Metab Dispos. 2018 Aug;46(8):1075-1082. doi: 10.1124/dmd.118.081125. Epub 2018 May 18. Drug Metab Dispos. 2018. PMID: 29777022

2

Metabolism and disposition of [14C]brivanib alaninate after oral administration to rats, monkeys, and humans.

Gong J, Gan J, Caceres-Cortes J, Christopher LJ, Arora V, Masson E, Williams D, Pursley J, Allentoff A, Lago M, Tran SB, Iyer RA. Gong J, et al. Drug Metab Dispos. 2011 May;39(5):891-903. doi: 10.1124/dmd.110.037341. Epub 2011 Feb 2. Drug Metab Dispos. 2011. PMID: 21289073

3

Physiologically-based pharmacokinetic modelling of a CYP2C19 substrate, BMS-823778, utilizing pharmacogenetic data.

Gong J, Iacono L, Iyer RA, Humphreys WG, Zheng M. Gong J, et al. Br J Clin Pharmacol. 2018 Jun;84(6):1335-1345. doi: 10.1111/bcp.13565. Epub 2018 Apr 10. Br J Clin Pharmacol. 2018. PMID: 29469197 Free PMC article.

4

Characterization of ADME properties of [(14)C]asunaprevir (BMS-650032) in humans.

Gong J, Eley T, He B, Arora V, Philip T, Jiang H, Easter J, Humphreys WG, Iyer RA, Li W. Gong J, et al. Xenobiotica. 2016;46(1):52-64. doi: 10.3109/00498254.2015.1048487. Epub 2015 Jul 7. Xenobiotica. 2016. PMID: 26153443 Clinical Trial.

5

Clinical significance of CYP2C19 polymorphisms on the metabolism and pharmacokinetics of 11β-hydroxysteroid dehydrogenase type-1 inhibitor BMS-823778.

Cheng Y, Wang L, Iacono L, Zhang D, Chen W, Gong J, Humphreys WG, Gan J. Cheng Y, et al. Among authors: gong j. Br J Clin Pharmacol. 2018 Jan;84(1):130-141. doi: 10.1111/bcp.13421. Epub 2017 Oct 4. Br J Clin Pharmacol. 2018. PMID: 28850715 Free PMC article. Clinical Trial.

6

Metabolic chiral inversion of brivanib and its relevance to safety and pharmacology.

Gong J, Gan J, Masson E, Syed S, Xia YQ, Williams D, Pursley J, Jemal M, Humphreys WG, Iyer RA. Gong J, et al. Drug Metab Dispos. 2012 Dec;40(12):2374-80. doi: 10.1124/dmd.112.047340. Epub 2012 Sep 14. Drug Metab Dispos. 2012. PMID: 22983304

7

Clinical Pharmacokinetics and the Impact of Genetic Polymorphism on a CYP2C19 Substrate, BMS-823778, in Healthy Subjects.

Gong J, Hansen L, Iacono L. Gong J, et al. Drug Metab Dispos. 2018 Mar;46(3):316-325. doi: 10.1124/dmd.117.078824. Epub 2018 Jan 8. Drug Metab Dispos. 2018. PMID: 29311135 Clinical Trial.

8

Identification of the oxidative and conjugative enzymes involved in the biotransformation of brivanib.

Gong J, Gan J, Iyer RA. Gong J, et al. Drug Metab Dispos. 2012 Jan;40(1):219-26. doi: 10.1124/dmd.111.042457. Epub 2011 Oct 11. Drug Metab Dispos. 2012. PMID: 21989950

9

Metabolism, excretion, and pharmacokinetics of oral brivanib in patients with advanced or metastatic solid tumors.

Mekhail T, Masson E, Fischer BS, Gong J, Iyer R, Gan J, Pursley J, Patricia D, Williams D, Ganapathi R. Mekhail T, et al. Among authors: gong j. Drug Metab Dispos. 2010 Nov;38(11):1962-6. doi: 10.1124/dmd.110.033951. Epub 2010 Jul 29. Drug Metab Dispos. 2010. PMID: 20671097 Free PMC article. Clinical Trial.

10

Quantitative analysis of polyethylene glycol (PEG) and PEGylated proteins in animal tissues by LC-MS/MS coupled with in-source CID.

Gong J, Gu X, Achanzar WE, Chadwick KD, Gan J, Brock BJ, Kishnani NS, Humphreys WG, Iyer RA. Gong J, et al. Anal Chem. 2014 Aug 5;86(15):7642-9. doi: 10.1021/ac501507g. Epub 2014 Jul 8. Anal Chem. 2014. PMID: 25003239

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