Perera V - Search Results

1

Further Studies to Support the Use of Coproporphyrin I and III as Novel Clinical Biomarkers for Evaluating the Potential for Organic Anion Transporting Polypeptide 1B1 and OATP1B3 Inhibition.

Shen H, Christopher L, Lai Y, Gong J, Kandoussi H, Garonzik S, Perera V, Garimella T, Humphreys WG. Shen H, et al. Among authors: perera v. Drug Metab Dispos. 2018 Aug;46(8):1075-1082. doi: 10.1124/dmd.118.081125. Epub 2018 May 18. Drug Metab Dispos. 2018. PMID: 29777022

2

Antithrombotic Effects of Combined PAR (Protease-Activated Receptor)-4 Antagonism and Factor Xa Inhibition.

Meah MN, Raftis J, Wilson SJ, Perera V, Garonzik SM, Murthy B, Everlof JG, Aronson R, Luettgen J, Newby DE. Meah MN, et al. Among authors: perera v. Arterioscler Thromb Vasc Biol. 2020 Nov;40(11):2678-2685. doi: 10.1161/ATVBAHA.120.314960. Epub 2020 Sep 10. Arterioscler Thromb Vasc Biol. 2020. PMID: 32907366 Free PMC article. Clinical Trial.

3

Effects of Itraconazole and Diltiazem on the Pharmacokinetics and Pharmacodynamics of Milvexian, A Factor XIa Inhibitor.

Perera V, Wang Z, Lubin S, Christopher LJ, Chen W, Xu S, Seiffert D, DeSouza M, Murthy B. Perera V, et al. Cardiol Ther. 2022 Sep;11(3):407-419. doi: 10.1007/s40119-022-00266-6. Epub 2022 May 31. Cardiol Ther. 2022. PMID: 35641780 Free PMC article.

4

Effects of rifampin on the pharmacokinetics and pharmacodynamics of milvexian, a potent, selective, oral small molecule factor XIa inhibitor.

Perera V, Wang Z, Lubin S, Christopher LJ, Chen W, Xu S, Seiffert D, DeSouza M, Murthy B. Perera V, et al. Sci Rep. 2022 Dec 23;12(1):22239. doi: 10.1038/s41598-022-25936-2. Sci Rep. 2022. PMID: 36564395 Free PMC article. Clinical Trial.

5

A pharmacometric approach to investigate the impact of methylxanthine abstinence and caffeine consumption on CYP1A2 activity.

Perera V, Gross AS, Forrest A, Landersdorfer CB, Xu H, Ait-Oudhia S, McLachlan AJ. Perera V, et al. Drug Metab Dispos. 2013 Nov;41(11):1957-66. doi: 10.1124/dmd.113.053074. Epub 2013 Aug 30. Drug Metab Dispos. 2013. PMID: 23996078

6

Prediction of olanzapine exposure in individual patients using physiologically based pharmacokinetic modelling and simulation.

Polasek TM, Tucker GT, Sorich MJ, Wiese MD, Mohan T, Rostami-Hodjegan A, Korprasertthaworn P, Perera V, Rowland A. Polasek TM, et al. Among authors: perera v. Br J Clin Pharmacol. 2018 Mar;84(3):462-476. doi: 10.1111/bcp.13480. Epub 2018 Jan 11. Br J Clin Pharmacol. 2018. PMID: 29194718 Free PMC article.

7

First-in-human study of milvexian, an oral, direct, small molecule factor XIa inhibitor.

Perera V, Wang Z, Luettgen J, Li D, DeSouza M, Cerra M, Seiffert D. Perera V, et al. Clin Transl Sci. 2022 Feb;15(2):330-342. doi: 10.1111/cts.13148. Epub 2021 Sep 24. Clin Transl Sci. 2022. PMID: 34558200 Free PMC article. Clinical Trial.

8

First-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS-962212, a direct, reversible, small molecule factor XIa inhibitor in non-Japanese and Japanese healthy subjects.

Perera V, Luettgen JM, Wang Z, Frost CE, Yones C, Russo C, Lee J, Zhao Y, LaCreta FP, Ma X, Knabb RM, Seiffert D, DeSouza M, Mugnier P, Cirincione B, Ueno T, Frost RJA. Perera V, et al. Br J Clin Pharmacol. 2018 May;84(5):876-887. doi: 10.1111/bcp.13520. Epub 2018 Mar 5. Br J Clin Pharmacol. 2018. PMID: 29346838 Free PMC article. Clinical Trial.

9

Phase I study of single-dose pharmacokinetics and pharmacodynamics of belatacept in adolescent kidney transplant recipients.

Moudgil A, Dharnidharka VR, Feig DI, Warshaw BL, Perera V, Murthy B, Roberts ME, Polinsky MS, Ettenger RB. Moudgil A, et al. Among authors: perera v. Am J Transplant. 2019 Apr;19(4):1218-1223. doi: 10.1111/ajt.15236. Epub 2019 Jan 22. Am J Transplant. 2019. PMID: 30582294 Free PMC article. Clinical Trial.

10

Single-Dose Pharmacokinetics of Milvexian in Participants with Mild or Moderate Hepatic Impairment Compared with Healthy Participants.

Perera V, Abelian G, Li D, Wang Z, Zhang L, Lubin S, Chen W, Bello A, Murthy B. Perera V, et al. Clin Pharmacokinet. 2022 Jun;61(6):857-867. doi: 10.1007/s40262-022-01110-9. Epub 2022 Mar 9. Clin Pharmacokinet. 2022. PMID: 35262846 Free PMC article. Clinical Trial.

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