Hawes B - Search Results

1

Discovery of MK-8282 as a Potent G-Protein-Coupled Receptor 119 Agonist for the Treatment of Type 2 Diabetes.

Neelamkavil SF, Stamford AW, Kowalski T, Biswas D, Boyle C, Chackalamannil S, Xia Y, Jayne C, Neustadt B, Hao J, Liu H, Dai X, Baker H, Hawes B, O'Neill K, Tang H, Greenlee WJ. Neelamkavil SF, et al. Among authors: hawes b. ACS Med Chem Lett. 2018 Apr 10;9(5):457-461. doi: 10.1021/acsmedchemlett.8b00073. eCollection 2018 May 10. ACS Med Chem Lett. 2018. PMID: 29795759 Free PMC article.

2

Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes.

Xia Y, Chackalamannil S, Greenlee WJ, Jayne C, Neustadt B, Stamford A, Vaccaro H, Xu XL, Baker H, O'Neill K, Woods M, Hawes B, Kowalski T. Xia Y, et al. Among authors: hawes b. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3290-6. doi: 10.1016/j.bmcl.2011.04.035. Epub 2011 Apr 14. Bioorg Med Chem Lett. 2011. PMID: 21536438

3

Discovery of the oxazabicyclo[3.3.1]nonane derivatives as potent and orally active GPR119 agonists.

Dai X, Stamford A, Liu H, Neustadt B, Hao J, Kowalski T, Hawes B, Xu X, Baker H, O'Neill K, Woods M, Tang H, Greenlee W. Dai X, et al. Among authors: hawes b. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5291-4. doi: 10.1016/j.bmcl.2015.09.047. Epub 2015 Sep 21. Bioorg Med Chem Lett. 2015. PMID: 26433449

4

Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity.

Palani A, Shapiro S, McBriar MD, Clader JW, Greenlee WJ, Spar B, Kowalski TJ, Farley C, Cook J, van Heek M, Weig B, O'neill K, Graziano M, Hawes B. Palani A, et al. Among authors: hawes b. J Med Chem. 2005 Jul 28;48(15):4746-9. doi: 10.1021/jm0503852. J Med Chem. 2005. PMID: 16033253

5

Biaryl diamides as potent melanin concentrating hormone receptor 1 antagonists.

Palani A, Shapiro S, McBriar MD, Clader JW, Greenlee WJ, O'Neill K, Hawes B. Palani A, et al. Among authors: hawes b. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5234-6. doi: 10.1016/j.bmcl.2005.08.043. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16202583

6

Discovery of hydroxy pyrimidine Factor IXa inhibitors.

Jayne CL, Andreani T, Chan TY, Chelliah MV, Clasby MC, Dwyer M, Eagen KA, Fried S, Greenlee WJ, Guo Z, Hawes B, Hruza A, Ingram R, Keertikar KM, Neelamkavil S, Reichert P, Xia Y, Chackalamannil S. Jayne CL, et al. Among authors: hawes b. Bioorg Med Chem Lett. 2020 Aug 1;30(15):127279. doi: 10.1016/j.bmcl.2020.127279. Epub 2020 May 23. Bioorg Med Chem Lett. 2020. PMID: 32527459

7

Discovery of melanin-concentrating hormone receptor R1 antagonists using high-throughput synthesis.

Su J, McKittrick BA, Tang H, Czarniecki M, Greenlee WJ, Hawes BE, O'Neill K. Su J, et al. Bioorg Med Chem. 2005 Mar 1;13(5):1829-36. doi: 10.1016/j.bmc.2004.11.046. Bioorg Med Chem. 2005. PMID: 15698800

8

Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics.

McBriar MD, Guzik H, Xu R, Paruchova J, Li S, Palani A, Clader JW, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar B, Weig B. McBriar MD, et al. Among authors: hawes be. J Med Chem. 2005 Apr 7;48(7):2274-7. doi: 10.1021/jm049035q. J Med Chem. 2005. PMID: 15801820

9

Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.

McBriar MD, Guzik H, Shapiro S, Paruchova J, Xu R, Palani A, Clader JW, Cox K, Greenlee WJ, Hawes BE, Kowalski TJ, O'neill K, Spar BD, Weig B, Weston DJ, Farley C, Cook J. McBriar MD, et al. Among authors: hawes be. J Med Chem. 2006 Apr 6;49(7):2294-310. doi: 10.1021/jm050886n. J Med Chem. 2006. PMID: 16570926

10

Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists.

Wu WL, Burnett DA, Caplen MA, Domalski MS, Bennett C, Greenlee WJ, Hawes BE, O'Neill K, Weig B, Weston D, Spar B, Kowalski T. Wu WL, et al. Among authors: hawes be. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3674-8. doi: 10.1016/j.bmcl.2006.04.062. Epub 2006 May 11. Bioorg Med Chem Lett. 2006. PMID: 16690315

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