Pasunooti KK - Search Results

1

Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP).

Bauer L, Ferla S, Head SA, Bhat S, Pasunooti KK, Shi WQ, Albulescu L, Liu JO, Brancale A, van Kuppeveld FJM, Strating JRPM. Bauer L, et al. Among authors: pasunooti kk. Antiviral Res. 2018 Aug;156:55-63. doi: 10.1016/j.antiviral.2018.05.010. Epub 2018 May 26. Antiviral Res. 2018. PMID: 29807040 Free article.

2

Design and Synthesis of Tetrazole- and Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors.

Li Y, Pasunooti KK, Peng H, Li RJ, Shi WQ, Liu W, Cheng Z, Head SA, Liu JO. Li Y, et al. Among authors: pasunooti kk. ACS Med Chem Lett. 2020 Apr 8;11(6):1111-1117. doi: 10.1021/acsmedchemlett.9b00438. eCollection 2020 Jun 11. ACS Med Chem Lett. 2020. PMID: 32550989 Free PMC article.

3

Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.

Head SA, Shi WQ, Yang EJ, Nacev BA, Hong SY, Pasunooti KK, Li RJ, Shim JS, Liu JO. Head SA, et al. Among authors: pasunooti kk. ACS Chem Biol. 2017 Jan 20;12(1):174-182. doi: 10.1021/acschembio.6b00849. Epub 2016 Dec 2. ACS Chem Biol. 2017. PMID: 28103683 Free PMC article.

4

Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells.

Head SA, Shi W, Zhao L, Gorshkov K, Pasunooti K, Chen Y, Deng Z, Li RJ, Shim JS, Tan W, Hartung T, Zhang J, Zhao Y, Colombini M, Liu JO. Head SA, et al. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7276-85. doi: 10.1073/pnas.1512867112. Epub 2015 Dec 10. Proc Natl Acad Sci U S A. 2015. PMID: 26655341 Free PMC article.

5

Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition.

Li Y, Pasunooti KK, Li RJ, Liu W, Head SA, Shi WQ, Liu JO. Li Y, et al. Among authors: pasunooti kk. J Med Chem. 2018 Dec 27;61(24):11158-11168. doi: 10.1021/acs.jmedchem.8b01252. Epub 2018 Dec 10. J Med Chem. 2018. PMID: 30481027

6

Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N¹)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.

Zhong W, Pasunooti KK, Balamkundu S, Wong YH, Nah Q, Gadi V, Gnanakalai S, Chionh YH, McBee ME, Gopal P, Lim SH, Olivier N, Buurman ET, Dick T, Liu CF, Lescar J, Dedon PC. Zhong W, et al. Among authors: pasunooti kk. J Med Chem. 2019 Sep 12;62(17):7788-7805. doi: 10.1021/acs.jmedchem.9b00582. Epub 2019 Aug 29. J Med Chem. 2019. PMID: 31442049 Free PMC article.

7

Dual native chemical ligation at lysine.

Yang R, Pasunooti KK, Li F, Liu XW, Liu CF. Yang R, et al. Among authors: pasunooti kk. J Am Chem Soc. 2009 Sep 30;131(38):13592-3. doi: 10.1021/ja905491p. J Am Chem Soc. 2009. PMID: 19728708

8

Adamantyl derivative as a potent inhibitor of Plasmodium FK506 binding protein 35.

Harikishore A, Leow ML, Niang M, Rajan S, Pasunooti KK, Preiser PR, Liu X, Yoon HS. Harikishore A, et al. Among authors: pasunooti kk. ACS Med Chem Lett. 2013 Sep 16;4(11):1097-101. doi: 10.1021/ml400306r. eCollection 2013 Nov 14. ACS Med Chem Lett. 2013. PMID: 24900611 Free PMC article.

9

Benzofuran-based estrogen receptor α modulators as anti-cancer therapeutics: in silico and experimental studies.

Leow ML, Chin HL, Yu PS, Pasunooti KK, Tay RX, Zhang D, Yoon HS, Liu XW. Leow ML, et al. Among authors: pasunooti kk. Curr Med Chem. 2013;20(22):2820-37. doi: 10.2174/0929867311320220007. Curr Med Chem. 2013. PMID: 23531218

10

Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine.

Yang R, Pasunooti KK, Li F, Liu XW, Liu CF. Yang R, et al. Among authors: pasunooti kk. Chem Commun (Camb). 2010 Oct 14;46(38):7199-201. doi: 10.1039/c0cc01382j. Epub 2010 Aug 25. Chem Commun (Camb). 2010. PMID: 20737108

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