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Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP).
Bauer L, Ferla S, Head SA, Bhat S, Pasunooti KK, Shi WQ, Albulescu L, Liu JO, Brancale A, van Kuppeveld FJM, Strating JRPM. Bauer L, et al. Among authors: van kuppeveld fjm. Antiviral Res. 2018 Aug;156:55-63. doi: 10.1016/j.antiviral.2018.05.010. Epub 2018 May 26. Antiviral Res. 2018. PMID: 29807040 Free article.
Synthesis and biological properties of novel brefeldin A analogues.
Seehafer K, Rominger F, Helmchen G, Langhans M, Robinson DG, Özata B, Brügger B, Strating JR, van Kuppeveld FJ, Klein CD. Seehafer K, et al. J Med Chem. 2013 Jul 25;56(14):5872-84. doi: 10.1021/jm400615g. Epub 2013 Jul 8. J Med Chem. 2013. PMID: 23805957
A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.
van der Schaar HM, Leyssen P, Thibaut HJ, de Palma A, van der Linden L, Lanke KH, Lacroix C, Verbeken E, Conrath K, Macleod AM, Mitchell DR, Palmer NJ, van de Poël H, Andrews M, Neyts J, van Kuppeveld FJ. van der Schaar HM, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):4971-81. doi: 10.1128/AAC.01175-13. Epub 2013 Jul 29. Antimicrob Agents Chemother. 2013. PMID: 23896472 Free PMC article.
Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.
Strating JR, van der Linden L, Albulescu L, Bigay J, Arita M, Delang L, Leyssen P, van der Schaar HM, Lanke KH, Thibaut HJ, Ulferts R, Drin G, Schlinck N, Wubbolts RW, Sever N, Head SA, Liu JO, Beachy PA, De Matteis MA, Shair MD, Olkkonen VM, Neyts J, van Kuppeveld FJ. Strating JR, et al. Cell Rep. 2015 Feb 3;10(4):600-15. doi: 10.1016/j.celrep.2014.12.054. Epub 2015 Jan 29. Cell Rep. 2015. PMID: 25640182 Free PMC article.
264 results