Liu DR - Search Results

1

Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction.

Koblan LW, Doman JL, Wilson C, Levy JM, Tay T, Newby GA, Maianti JP, Raguram A, Liu DR. Koblan LW, et al. Among authors: liu dr. Nat Biotechnol. 2018 Oct;36(9):843-846. doi: 10.1038/nbt.4172. Epub 2018 May 29. Nat Biotechnol. 2018. PMID: 29813047 Free PMC article.

2

A system for the continuous directed evolution of biomolecules.

Esvelt KM, Carlson JC, Liu DR. Esvelt KM, et al. Among authors: liu dr. Nature. 2011 Apr 28;472(7344):499-503. doi: 10.1038/nature09929. Epub 2011 Apr 10. Nature. 2011. PMID: 21478873 Free PMC article.

3

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity.

Pattanayak V, Lin S, Guilinger JP, Ma E, Doudna JA, Liu DR. Pattanayak V, et al. Among authors: liu dr. Nat Biotechnol. 2013 Sep;31(9):839-43. doi: 10.1038/nbt.2673. Epub 2013 Aug 11. Nat Biotechnol. 2013. PMID: 23934178 Free PMC article.

4

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification.

Guilinger JP, Thompson DB, Liu DR. Guilinger JP, et al. Among authors: liu dr. Nat Biotechnol. 2014 Jun;32(6):577-582. doi: 10.1038/nbt.2909. Epub 2014 Apr 25. Nat Biotechnol. 2014. PMID: 24770324 Free PMC article.

5

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.

Maianti JP, McFedries A, Foda ZH, Kleiner RE, Du XQ, Leissring MA, Tang WJ, Charron MJ, Seeliger MA, Saghatelian A, Liu DR. Maianti JP, et al. Among authors: liu dr. Nature. 2014 Jul 3;511(7507):94-8. doi: 10.1038/nature13297. Epub 2014 May 21. Nature. 2014. PMID: 24847884 Free PMC article.

6

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage.

Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR. Komor AC, et al. Among authors: liu dr. Nature. 2016 May 19;533(7603):420-4. doi: 10.1038/nature17946. Epub 2016 Apr 20. Nature. 2016. PMID: 27096365 Free PMC article.

7

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions.

Kim YB, Komor AC, Levy JM, Packer MS, Zhao KT, Liu DR. Kim YB, et al. Among authors: liu dr. Nat Biotechnol. 2017 Apr;35(4):371-376. doi: 10.1038/nbt.3803. Epub 2017 Feb 13. Nat Biotechnol. 2017. PMID: 28191901 Free PMC article.

8

Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery.

Rees HA, Komor AC, Yeh WH, Caetano-Lopes J, Warman M, Edge ASB, Liu DR. Rees HA, et al. Among authors: liu dr. Nat Commun. 2017 Jun 6;8:15790. doi: 10.1038/ncomms15790. Nat Commun. 2017. PMID: 28585549 Free PMC article.

9

Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation.

Tang W, Hu JH, Liu DR. Tang W, et al. Among authors: liu dr. Nat Commun. 2017 Jun 28;8:15939. doi: 10.1038/ncomms15939. Nat Commun. 2017. PMID: 28656978 Free PMC article.

10

Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity.

Komor AC, Zhao KT, Packer MS, Gaudelli NM, Waterbury AL, Koblan LW, Kim YB, Badran AH, Liu DR. Komor AC, et al. Among authors: liu dr. Sci Adv. 2017 Aug 30;3(8):eaao4774. doi: 10.1126/sciadv.aao4774. eCollection 2017 Aug. Sci Adv. 2017. PMID: 28875174 Free PMC article.

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