Zhuang Z - Search Results

1

Pharmacologic inhibition of protein phosphatase-2A achieves durable immune-mediated antitumor activity when combined with PD-1 blockade.

Ho WS, Wang H, Maggio D, Kovach JS, Zhang Q, Song Q, Marincola FM, Heiss JD, Gilbert MR, Lu R, Zhuang Z. Ho WS, et al. Among authors: zhuang z. Nat Commun. 2018 May 29;9(1):2126. doi: 10.1038/s41467-018-04425-z. Nat Commun. 2018. PMID: 29844427 Free PMC article.

2

Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms.

Lu J, Kovach JS, Johnson F, Chiang J, Hodes R, Lonser R, Zhuang Z. Lu J, et al. Among authors: zhuang z. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11697-702. doi: 10.1073/pnas.0905930106. Epub 2009 Jun 29. Proc Natl Acad Sci U S A. 2009. PMID: 19564615 Free PMC article.

3

Enhancement of cancer chemotherapy by simultaneously altering cell cycle progression and DNA-damage defenses through global modification of the serine/threonine phospho-proteome.

Zhuang Z, Lu J, Lonser R, Kovach JS. Zhuang Z, et al. Cell Cycle. 2009 Oct 15;8(20):3303-6. doi: 10.4161/cc.8.20.9689. Epub 2009 Oct 31. Cell Cycle. 2009. PMID: 19806030

4

Von hippel-lindau disease associated pulmonary carcinoid with cranial metastasis.

Zhang C, Yang AI, Vasconcelos L, Moon S, Yang C, Nesvick CL, Saidkhodjaeva L, Abdullaev Z, Pack SD, Ghosh A, Chittiboina P, Heiss JD, Zhuang Z, Quezado MM, Zaghloul KA. Zhang C, et al. Among authors: zhuang z. J Clin Endocrinol Metab. 2014 Aug;99(8):2633-6. doi: 10.1210/jc.2014-1732. Epub 2014 May 30. J Clin Endocrinol Metab. 2014. PMID: 24878057 Free PMC article.

5

Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair.

Lv P, Wang Y, Ma J, Wang Z, Li JL, Hong CS, Zhuang Z, Zeng YX. Lv P, et al. Among authors: zhuang z. Oncotarget. 2014 Sep 15;5(17):7512-24. doi: 10.18632/oncotarget.2258. Oncotarget. 2014. PMID: 25245035 Free PMC article.

6

Inhibition of protein phosphatase 2A sensitizes pancreatic cancer to chemotherapy by increasing drug perfusion via HIF-1α-VEGF mediated angiogenesis.

Bai X, Zhi X, Zhang Q, Liang F, Chen W, Liang C, Hu Q, Sun X, Zhuang Z, Liang T. Bai X, et al. Among authors: zhuang z. Cancer Lett. 2014 Dec 28;355(2):281-7. doi: 10.1016/j.canlet.2014.09.048. Epub 2014 Oct 7. Cancer Lett. 2014. PMID: 25304380

7

The protein phosphatase 2A inhibitor LB100 sensitizes ovarian carcinoma cells to cisplatin-mediated cytotoxicity.

Chang KE, Wei BR, Madigan JP, Hall MD, Simpson RM, Zhuang Z, Gottesman MM. Chang KE, et al. Among authors: zhuang z. Mol Cancer Ther. 2015 Jan;14(1):90-100. doi: 10.1158/1535-7163.MCT-14-0496. Epub 2014 Nov 5. Mol Cancer Ther. 2015. PMID: 25376608 Free PMC article.

8

Mutant glucocerebrosidase in Gaucher disease recruits Hsp27 to the Hsp90 chaperone complex for proteasomal degradation.

Yang C, Wang H, Zhu D, Hong CS, Dmitriev P, Zhang C, Li Y, Ikejiri B, Brady RO, Zhuang Z. Yang C, et al. Among authors: zhuang z. Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1137-42. doi: 10.1073/pnas.1424288112. Epub 2015 Jan 12. Proc Natl Acad Sci U S A. 2015. PMID: 25583479 Free PMC article.

9

New developments in the pathogenesis and therapeutic targeting of the IDH1 mutation in glioma.

Dimitrov L, Hong CS, Yang C, Zhuang Z, Heiss JD. Dimitrov L, et al. Among authors: zhuang z. Int J Med Sci. 2015 Jan 20;12(3):201-13. doi: 10.7150/ijms.11047. eCollection 2015. Int J Med Sci. 2015. PMID: 25678837 Free PMC article. Review.

10

LB100, a small molecule inhibitor of PP2A with potent chemo- and radio-sensitizing potential.

Hong CS, Ho W, Zhang C, Yang C, Elder JB, Zhuang Z. Hong CS, et al. Among authors: zhuang z. Cancer Biol Ther. 2015;16(6):821-33. doi: 10.1080/15384047.2015.1040961. Epub 2015 Apr 21. Cancer Biol Ther. 2015. PMID: 25897893 Free PMC article. Review.

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