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A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and Type 2 diabetes.
Vogel H, Kamitz A, Hallahan N, Lebek S, Schallschmidt T, Jonas W, Jähnert M, Gottmann P, Zellner L, Kanzleiter T, Damen M, Altenhofen D, Burkhardt R, Renner S, Dahlhoff M, Wolf E, Müller TD, Blüher M, Joost HG, Chadt A, Al-Hasani H, Schürmann A. Vogel H, et al. Among authors: altenhofen d. Hum Mol Genet. 2018 Sep 1;27(17):3099-3112. doi: 10.1093/hmg/ddy217. Hum Mol Genet. 2018. PMID: 29893858 Free PMC article.
Two Novel Candidate Genes for Insulin Secretion Identified by Comparative Genomics of Multiple Backcross Mouse Populations.
Schallschmidt T, Lebek S, Altenhofen D, Damen M, Schulte Y, Knebel B, Herwig R, Rasche A, Stermann T, Kamitz A, Hallahan N, Jähnert M, Vogel H, Schürmann A, Chadt A, Al-Hasani H. Schallschmidt T, et al. Among authors: altenhofen d. Genetics. 2018 Dec;210(4):1527-1542. doi: 10.1534/genetics.118.301578. Epub 2018 Oct 19. Genetics. 2018. PMID: 30341086 Free PMC article.
Alternative exon splicing and differential expression in pancreatic islets reveals candidate genes and pathways implicated in early diabetes development.
Rehman SU, Schallschmidt T, Rasche A, Knebel B, Stermann T, Altenhofen D, Herwig R, Schürmann A, Chadt A, Al-Hasani H. Rehman SU, et al. Among authors: altenhofen d. Mamm Genome. 2021 Jun;32(3):153-172. doi: 10.1007/s00335-021-09869-1. Epub 2021 Apr 20. Mamm Genome. 2021. PMID: 33880624 Free PMC article.
Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes.
Görigk S, Ouwens DM, Kuhn T, Altenhofen D, Binsch C, Damen M, Khuong JM, Kaiser K, Knebel B, Vogel H, Schürmann A, Chadt A, Al-Hasani H. Görigk S, et al. Among authors: altenhofen d. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Jun;1867(6):159153. doi: 10.1016/j.bbalip.2022.159153. Epub 2022 Mar 31. Biochim Biophys Acta Mol Cell Biol Lipids. 2022. PMID: 35367353
Deletion of the RabGAP TBC1D1 Leads to Enhanced Insulin Secretion and Fatty Acid Oxidation in Islets From Male Mice.
Stermann T, Menzel F, Weidlich C, Jeruschke K, Weiss J, Altenhofen D, Benninghoff T, Pujol A, Bosch F, Rustenbeck I, Ouwens DM, Thoresen GH, de Wendt C, Lebek S, Schallschmidt T, Kragl M, Lammert E, Chadt A, Al-Hasani H. Stermann T, et al. Among authors: altenhofen d. Endocrinology. 2018 Apr 1;159(4):1748-1761. doi: 10.1210/en.2018-00087. Endocrinology. 2018. PMID: 29481597
Histone deacetylase 5 regulates interleukin 6 secretion and insulin action in skeletal muscle.
Klymenko O, Brecklinghaus T, Dille M, Springer C, de Wendt C, Altenhofen D, Binsch C, Knebel B, Scheller J, Hardt C, Herwig R, Chadt A, Pfluger PT, Al-Hasani H, Kabra DG. Klymenko O, et al. Among authors: altenhofen d. Mol Metab. 2020 Dec;42:101062. doi: 10.1016/j.molmet.2020.101062. Epub 2020 Aug 6. Mol Metab. 2020. PMID: 32771698 Free PMC article.
Acute effect of 3β-hidroxihop-22(29)ene on insulin secretion is mediated by GLP-1, potassium and calcium channels for the glucose homeostasis.
Castro AJ, Cazarolli LH, de Carvalho FK, da Luz G, Altenhofen D, dos Santos AR, Pizzolatti MG, Silva FR. Castro AJ, et al. Among authors: altenhofen d. J Steroid Biochem Mol Biol. 2015 Jun;150:112-22. doi: 10.1016/j.jsbmb.2015.03.011. Epub 2015 Apr 2. J Steroid Biochem Mol Biol. 2015. PMID: 25843210 Free article.
16 results