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A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and Type 2 diabetes.
Vogel H, Kamitz A, Hallahan N, Lebek S, Schallschmidt T, Jonas W, Jähnert M, Gottmann P, Zellner L, Kanzleiter T, Damen M, Altenhofen D, Burkhardt R, Renner S, Dahlhoff M, Wolf E, Müller TD, Blüher M, Joost HG, Chadt A, Al-Hasani H, Schürmann A. Vogel H, et al. Among authors: muller td. Hum Mol Genet. 2018 Sep 1;27(17):3099-3112. doi: 10.1093/hmg/ddy217. Hum Mol Genet. 2018. PMID: 29893858 Free PMC article.
Animal models of obesity and diabetes mellitus.
Kleinert M, Clemmensen C, Hofmann SM, Moore MC, Renner S, Woods SC, Huypens P, Beckers J, de Angelis MH, Schürmann A, Bakhti M, Klingenspor M, Heiman M, Cherrington AD, Ristow M, Lickert H, Wolf E, Havel PJ, Müller TD, Tschöp MH. Kleinert M, et al. Among authors: muller td. Nat Rev Endocrinol. 2018 Mar;14(3):140-162. doi: 10.1038/nrendo.2017.161. Epub 2018 Jan 19. Nat Rev Endocrinol. 2018. PMID: 29348476 Free article. Review.
Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs.
Renner S, Blutke A, Dobenecker B, Dhom G, Müller TD, Finan B, Clemmensen C, Bernau M, Novak I, Rathkolb B, Senf S, Zöls S, Roth M, Götz A, Hofmann SM, Hrabĕ de Angelis M, Wanke R, Kienzle E, Scholz AM, DiMarchi R, Ritzmann M, Tschöp MH, Wolf E. Renner S, et al. Among authors: muller td. Mol Metab. 2018 Oct;16:180-190. doi: 10.1016/j.molmet.2018.06.015. Epub 2018 Jun 28. Mol Metab. 2018. PMID: 30017782 Free PMC article.
Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis.
Ruiz-Ojeda FJ, Wang J, Bäcker T, Krueger M, Zamani S, Rosowski S, Gruber T, Onogi Y, Feuchtinger A, Schulz TJ, Fässler R, Müller TD, García-Cáceres C, Meier M, Blüher M, Ussar S. Ruiz-Ojeda FJ, et al. Among authors: muller td. Mol Metab. 2021 Mar;45:101147. doi: 10.1016/j.molmet.2020.101147. Epub 2021 Jan 7. Mol Metab. 2021. PMID: 33359386 Free PMC article.
Anti-obesity drug discovery: advances and challenges.
Müller TD, Blüher M, Tschöp MH, DiMarchi RD. Müller TD, et al. Nat Rev Drug Discov. 2022 Mar;21(3):201-223. doi: 10.1038/s41573-021-00337-8. Epub 2021 Nov 23. Nat Rev Drug Discov. 2022. PMID: 34815532 Free PMC article. Review.
Pantothenate kinase 4 controls skeletal muscle substrate metabolism.
Miranda-Cervantes A, Fritzen AM, Raun SH, Hodek O, Møller LLV, Johann K, Deisen L, Gregorevic P, Gudiksen A, Artati A, Adamski J, Andersen NR, Sigvardsen CM, Carl CS, Voldstedlund CT, Kjøbsted R, Hauck SM, Schjerling P, Jensen TE, Cebrian-Serrano A, Jähnert M, Gottmann P, Burtscher I, Lickert H, Pilegaard H, Schürmann A, Tschöp MH, Moritz T, Müller TD, Sylow L, Kiens B, Richter EA, Kleinert M. Miranda-Cervantes A, et al. Among authors: muller td. Nat Commun. 2025 Jan 2;16(1):345. doi: 10.1038/s41467-024-55036-w. Nat Commun. 2025. PMID: 39746949 Free PMC article.
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.
Scherag A, Dina C, Hinney A, Vatin V, Scherag S, Vogel CI, Müller TD, Grallert H, Wichmann HE, Balkau B, Heude B, Jarvelin MR, Hartikainen AL, Levy-Marchal C, Weill J, Delplanque J, Körner A, Kiess W, Kovacs P, Rayner NW, Prokopenko I, McCarthy MI, Schäfer H, Jarick I, Boeing H, Fisher E, Reinehr T, Heinrich J, Rzehak P, Berdel D, Borte M, Biebermann H, Krude H, Rosskopf D, Rimmbach C, Rief W, Fromme T, Klingenspor M, Schürmann A, Schulz N, Nöthen MM, Mühleisen TW, Erbel R, Jöckel KH, Moebus S, Boes T, Illig T, Froguel P, Hebebrand J, Meyre D. Scherag A, et al. Among authors: muller td. PLoS Genet. 2010 Apr 22;6(4):e1000916. doi: 10.1371/journal.pgen.1000916. PLoS Genet. 2010. PMID: 20421936 Free PMC article.
Reappraisal of GIP Pharmacology for Metabolic Diseases.
Finan B, Müller TD, Clemmensen C, Perez-Tilve D, DiMarchi RD, Tschöp MH. Finan B, et al. Among authors: muller td. Trends Mol Med. 2016 May;22(5):359-376. doi: 10.1016/j.molmed.2016.03.005. Epub 2016 Mar 30. Trends Mol Med. 2016. PMID: 27038883 Review.
Unimolecular Polypharmacy for Treatment of Diabetes and Obesity.
Tschöp MH, Finan B, Clemmensen C, Gelfanov V, Perez-Tilve D, Müller TD, DiMarchi RD. Tschöp MH, et al. Among authors: muller td. Cell Metab. 2016 Jul 12;24(1):51-62. doi: 10.1016/j.cmet.2016.06.021. Cell Metab. 2016. PMID: 27411008 Free article. Review.
205 results