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Non-competitive cyclic peptides for targeting enzyme-substrate complexes.
McAllister TE, Yeh TL, Abboud MI, Leung IKH, Hookway ES, King ONF, Bhushan B, Williams ST, Hopkinson RJ, Münzel M, Loik ND, Chowdhury R, Oppermann U, Claridge TDW, Goto Y, Suga H, Schofield CJ, Kawamura A. McAllister TE, et al. Among authors: chowdhury r. Chem Sci. 2018 Apr 23;9(20):4569-4578. doi: 10.1039/c8sc00286j. eCollection 2018 May 28. Chem Sci. 2018. PMID: 29899950 Free PMC article.
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Liénard BM, Zondlo J, Oldham NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJ, Hewitson KS, Yang E, Jordan S, Syed RS, Schofield CJ. McDonough MA, et al. Among authors: chowdhury r. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9814-9. doi: 10.1073/pnas.0601283103. Epub 2006 Jun 16. Proc Natl Acad Sci U S A. 2006. PMID: 16782814 Free PMC article.
Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.
Flashman E, Bagg EA, Chowdhury R, Mecinović J, Loenarz C, McDonough MA, Hewitson KS, Schofield CJ. Flashman E, et al. Among authors: chowdhury r. J Biol Chem. 2008 Feb 15;283(7):3808-15. doi: 10.1074/jbc.M707411200. Epub 2007 Dec 5. J Biol Chem. 2008. PMID: 18063574 Free article.
Evidence for a stereoelectronic effect in human oxygen sensing.
Loenarz C, Mecinović J, Chowdhury R, McNeill LA, Flashman E, Schofield CJ. Loenarz C, et al. Among authors: chowdhury r. Angew Chem Int Ed Engl. 2009;48(10):1784-7. doi: 10.1002/anie.200805427. Angew Chem Int Ed Engl. 2009. PMID: 19180614
2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
Mecinović J, Loenarz C, Chowdhury R, Schofield CJ. Mecinović J, et al. Among authors: chowdhury r. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6192-5. doi: 10.1016/j.bmcl.2009.09.005. Epub 2009 Sep 6. Bioorg Med Chem Lett. 2009. PMID: 19775891
1,251 results